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Case Reports in Pathology
Volume 2017, Article ID 7907359, 5 pages
Case Report

Leiomyosarcoma and Squamous Cell Carcinoma Arising in Mature Cystic Teratoma of the Ovary

1Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
2Uttaradit Hospital, Uttaradit, Thailand

Correspondence should be addressed to Tip Pongsuvareeyakul; moc.liamtoh@pit_gnat

Received 20 March 2017; Accepted 28 May 2017; Published 2 July 2017

Academic Editor: Tibor Tot

Copyright © 2017 Tip Pongsuvareeyakul et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The occurrence of malignant transformation in mature cystic teratoma of the ovary is rare, with squamous cell carcinoma being the most common histologic type. Sarcomatous transformation has been rarely described in the literature. We present a case of leiomyosarcoma with a minor component of squamous cell carcinoma arising in mature cystic teratoma of ovary in a 65-year-old woman. The malignant tumor showed two distinct components of sarcomatous and invasive epithelial elements, which were confirmed by immunostaining. To our knowledge, only four cases of leiomyosarcoma in ovarian mature cystic teratoma have been reported and this is a unique case report of leiomyosarcoma and squamous cell carcinoma arising in a mature cystic teratoma of ovary.