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Case Reports in Pathology
Volume 2017 (2017), Article ID 7931975, 6 pages
Case Report

Primary Hepatic Neuroendocrine Tumor with Unusual Thyroid Follicular-Like Morphologic Characteristics

1Division of Neurology, Massey Cancer Center, VCU Medical Center, Richmond, VA, USA
2Division of Nephrology and Hypertension, Mayo Clinic, Jacksonville, FL, USA
3Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL, USA

Correspondence should be addressed to Aziza Nassar; ude.oyam@aziza.rassan

Received 22 November 2016; Revised 31 January 2017; Accepted 2 February 2017; Published 20 February 2017

Academic Editor: Zsuzsa Schaff

Copyright © 2017 Mohd Elmugtaba Ibrahim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We describe a primary hepatic neuroendocrine tumor of a 57-year-old Thai woman who presented in 2004 with a suspicious mass in the left hepatic lobe. She underwent left hepatectomy for the 10.5-cm mass, called intermediate grade neuroendocrine carcinoma of unknown origin, likely metastatic. The tumor recurred in 2007, then called recurrent primary hepatic neuroendocrine tumor (PHNET), and the patient underwent liver transplant. Because of similarity between the neuroendocrine tumor and a thyroid tumor—specifically, follicular-like characteristics—immunohistochemical stains for thyroglobulin, TTF1, and calcitonin were performed. However, all were negative. All imaging studies revealed no evidence of a primary lesion other than the liver mass. In 2008, the patient’s liver transplant failed because of ischemic cholangiopathy, and she underwent a second liver transplant. Seven years later, in 2015, she presented with metastatic neuroendocrine tumor of intermediate grade to the lung, consistent with metastatic PHNET. She underwent left upper-lobe wedge resection to remove the tumor. The patient is alive with no evidence of disease at 13 years after initial diagnosis. This rare variant of PHNET had thyroid-like morphologic characteristics but there is no evidence of primary thyroid tumor or thyroid markers in the primary and recurrent hepatic tumors and lung metastasis.