Two Different Cell Populations Is an Important Clue for Diagnosis of Primary Cutaneous Adenoid Cystic Carcinoma: Immunohistochemical Study

Figure 1

Primer cutaneous adenoid cystic carcinoma (PCACC) (left two columns). Adenoid basal cell carcinoma (A-BCC) (right two columns). (a-b). Typical regular cribriform pattern is readily detected in PCACC. (c-d). However, pseudoluminal areas are not regular, and the well-defined cribriform patterns are not seen in A-BCC. CD117 (f) and CK7 (i) are positive in PCACCs but not in A-BCC (h, k). CD43 positivity is heterogenoeus in PCACC (e) but no positivity is detected except for inflammatory cells in A-BCC (g). BerEp4 positivity is seen in both lesions (j, l). A-BCC shows diffuse positivity (l), but only ductal cell positivity in PCACC (j). Original magnifications: (a, c) ×40; (b, e, f, g, h, i, k, l) ×100; (d, j) ×200.