Two Different Cell Populations Is an Important Clue for Diagnosis of Primary Cutaneous Adenoid Cystic Carcinoma: Immunohistochemical Study

Table 1

Summary of immunohistochemical studies in the literature.

IHC marker	Positivity	Percentage	Notes	References
PAN-keratin	10/10	100%	Including AE1/AE3 keratin	[4–11]
Alfa-lactalbumin	1/1	100%		[9]
Amylase	1/1	100%		[9]
Ber-ep4	1/2	50%		[12]
Blood group isoantigens	0/1	0%		[9]
B2-microglobulin	0/1	0%		[9]
Calponin	2/2	100%		[11]
CAM5.2	0/1	0%		[5]
CD10	1/2	50%		[5, 12]
CD43	2/3	66,6%		[13]
CD56	1/1	100%		[5]
CD57 (Leu7)	0/1	0%		[8]
CD117	37/37	100%		[1, 5, 6, 12–16]
CEA	24/33	72,7%	Focal, luminal positivity	[1, 5–8, 11, 12, 17–22]
CK5/6	17/17	100%		[5, 14]
CK7	20/20	100%		[5, 10, 12, 14]
CK10	0/1	0%		[10]
CK15	13/14	92,8%		[14]
CK18	1/1	100%		[10]
CK19	1/2	50%		[5, 12]
CK20	0/1	0%		[5]
D2-40	13/15	86,6%		[14]
EMA	27/30	90%	Focal, luminal positivity	[1, 4–6, 8, 9, 11, 12, 17–19, 22, 23]
GCDFP-15	0/1	50%		[12]
HMWCK	6/6	100%	Including 34Be12 clone	[5, 11, 17, 18, 21]
Laminin	3/3	100%		[17, 24]
LMWK	4/4	100%		[8, 17, 18, 21]
MNF-116	14/14	100%		[1, 22]
P16	1/1	100%		[16]
P63	17/19	89,4%		[5, 12, 14]
Peanut agglutinin (PNA)	1/1	100%		[9]
S-100	28/30	93,3%	Generally focal positivity	[1, 5–9, 11, 12, 17–23]
SMA	33/36	91,6%	Including one immunoflourescent study	[1, 5, 10, 11, 14, 18, 20]
SOX-10	19/19	100%		[14]
Type IV collagen	12/13	92,3%		[1, 17, 24]
Vimentin	13/16	81,2%		[8, 10, 14]

[4–12, 14, 15, 17–24].
Adenoid cystic carcinoma of the eye and eyelid excluded. Including this case.