Lipomatous/Extensively Vacuolated Ependymoma with Signet-Ring Cell-Like Appearance: Analysis of a Case with Extensive Literature Review

Figure 3

Immunohistochemistry panel/transmission electron microscopy. (a) Glial fibrillary acidic protein (GFAP). (b) CD99. (c) PS100. (d) Ki-67 (MIB-1). (e, f) Uni- and multivacuolated cells featuring void lumina. (g) Rough endoplasmic reticulum (blue arrowhead) near an empty vacuole (orange asterisk). There is no apparent connection between them. On the left side, a small part of the cell’s nucleus can be seen (green asterisk). (h) Hollow intracytoplasmic lumen containing granulofibrillary debris, slightly resembling degenerated microvilli or organelles, next to the nucleus (right field). (i) Microrosette filled with microvilli (green arrowhead) lying close to a dilated vacuole with granulofibrillary material (blue asterisk).

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