SMARCA4-Deficient Carcinoma of Unknown Primary Presenting with Fatal Paraneoplastic Hypercalcemia in a Heart Transplant Recipient: First Report in a Male Patient

<div>By immunohistochemistry, the neoplastic cells expressed strongly pancytokeratin with frequent paranuclear accentuation in the rhabdoid inclusions (a). The neoplastic cells were negative with HepPar-1 ((b) main image; see strongly stained hepatocytes) and CK7 ((b), inset; residual biliary tract epithelial cells are strongly stained). (c) CK20 was expressed in most of cells. (d) GATA3 was focally positive. Both of SMARCA4 (e) and SMARCA2 (f) are lost in the tumor cells (endothelial cells are strongly positive for both markers as internal control).</div>

Case Reports in Pathology

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Figure 3: SMARCA4-Deficient Carcinoma of Unknown Primary Presenting with Fatal Paraneoplastic Hypercalcemia in a Heart Transplant Recipient: First Report in a Male Patient 

Figure 3 | SMARCA4-Deficient Carcinoma of Unknown Primary Presenting with Fatal Paraneoplastic Hypercalcemia in a Heart Transplant Recipient: First Report in a Male Patient 