Langerhans Cell Sarcoma: A Case Report Demonstrating Morphological and Immunophenotypical Variability within a Single Lesion

Figure 4

S100 immunohistochemistry positivity was variable in the three biopsies; these images compare the S100 positivity from the three different biopsy sites. (a) shows that tumour cells are S100 positive; (b) shows that occasional tumour cells are S100 positive; (c) shows that tumour cells are negative for S100. This variability within a single cutaneous lesion has not been reported within a single LCS lesion.

(a)

(b)

(c)