Case Report
A Case Report: Gastric Mixed Neuroendocrine-Nonneuroendocrine Neoplasm with Aggressive Neuroendocrine Component
Table 2
Summary of immunoprofile.
| | Marker | First biopsy | Second biopsy
(interval) | Autopsy | Primary lesion
(stomach) | Secondary lesion
(liver) |
| | Synaptophysin | NEC (3+) | NEC (3+) | NEC (2+) | NEC (3+) | | CD56 | NEC (3+) | NEC (3+) | NEC (3+) | NEC (3+) | | Chromogranin A | NEC (2+) | NEC (2+) | NEC (2+) | NEC (3+) | | CEA | | | ADC (2+) | | | Her2 | ADC (3+) | No ADC | ADC (−) | No ADC | | Ki67 | NEC: 50–60% | | NEC: 20–30% | NEC: 30–40% | | ADC: 20–30% | | ADC: 20–30% | No ADC |
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NEC: neuroendocrine component. ADC: adenocarcinoma component. Ki67 index is calculated by manual eye-counting in hot spot with 40x magnification.
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