Case Reports in Pathology

Case Reports in Pathology / 2018 / Article

Case Report | Open Access

Volume 2018 |Article ID 5971786 |

Kanish Mirchia, Rana Naous, "Nasal Chondromesenchymal Hamartoma: Rare Case Report in an Elderly Patient and Brief Review of Literature", Case Reports in Pathology, vol. 2018, Article ID 5971786, 7 pages, 2018.

Nasal Chondromesenchymal Hamartoma: Rare Case Report in an Elderly Patient and Brief Review of Literature

Academic Editor: Stefan Pambuccian
Received29 May 2018
Accepted24 Sep 2018
Published14 Oct 2018


Hamartomas are considered a mixture of nonneoplastic tissue, which may be indigenous to a different location in the body. As such, they may be epithelial, mesenchymal, or mixed. In the sinonasal region, the following hamartomatous lesions are considered to lie on a spectrum and include respiratory epithelial adenomatoid hamartoma (REAH), chondro-osseous respiratory epithelial adenomatoid hamartoma (COREAH), and nasal chondromesenchymal hamartoma (NCMH). To our knowledge, less than 50 cases of sinonasal hamartomas have been reported in the English literature so far with NCMH being very rare and primarily a tumor in infancy, with only 2 cases reported in individuals older than 16 years of age. We report a highly unusual case of a NCMH in the right maxillary sinus of a 70-year-old female.

1. Case Report

A 70-year-old female presented with a two-year history of slowly growing, nonpainful maxillary sinus mass. She has a history of chronic maxillary sinusitis corresponding to presentation of the mass, with the first episode reported in 2014. Computed tomography (CT) imaging revealed an erosive right maxillary sinus mass (2.5 x 2.1 cm) with bony destruction.

Surgical excision of the right maxillary sinus mass revealed a fragmented, white, vaguely nodular, and whorled lesion. Histological examination revealed fragments of respiratory-type epithelium with focal cystic invagination and associated squamous metaplasia [Figure 1]. The underlying stroma consisted of a variably cellular, benign spindle cell proliferation with an associated background of hyalinization [Figure 2], calcification and ossification [Figure 3], and focal chondroid change [Figure 4] in a vague lobule-like arrangement. Focal areas of aneurysmal and cystic changes [Figure 5] were seen which would provide an explanation for the clinically noted enlargement since hamartomas by definition would be expected to have a much lower rate of growth. The intrinsic slow-growing nature is also supported by the deficit of mitotic activity even in the highly cellular/spindled regions of the lesion (less than 1/10 hpf). Areas with haphazard arrangement of nerve bundles within the collagenous stroma [Figure 6] were also noted. Immunohistochemical stains were positive for SMA [Figures 7(a) and 7(b)] in the spindle cells and negative for CK AE1/AE3, EMA, CD34, Stat6, ERG/FLI-1, Mucin 4, S-100, Sox-10, and desmin [Figure 8]; ruling out perineurioma, solitary fibrous tumor, a vascular neoplasm, Evans tumor, a benign peripheral nerve sheath tumor, or a myogenic neoplasm. The overall findings were suggestive of a hamartomatous lesion, most likely a nasal chondromesenchymal hamartoma. The absence of submucosal glandular proliferation, myxoid stroma, or mucinous metaplasia in the lining epithelium lowers the likelihood of other neoplastic hamartomatous lesions such as COREAH.

2. Discussion

Nasal chondromesenchymal hamartomas are most commonly seen in the nasal cavity of children less than 3 months old, with less common involvement of the paranasal sinuses [2]. As per one review [1], mean age for NCMH was 9.6 years. Review of the English PubMed literature reveals 43 cases [Table 1] of NCMH previously published, with our case being the oldest patient reported, and presenting with a tumor in an unusual location.

SitePertinent InformationStudyYear

5 daysM2 yearsNasal cavity-[2] McDermott1998

12 daysF< 16 monthsNasal cavityIntracranial extension[2] McDermott1998

14 daysM-Nasal cavity
Ethmoid Sinus
Intracranial extension
Residual tumor
[2] McDermott1998

2 monthsM18 monthsNasal cavityIntracranial extension[2] McDermott1998

3 monthsF2 yearsNasal cavity
Ethmoid Sinus
Intracranial extension
Residual tumor
[2] McDermott1998

3 monthsM4 yearsNasal cavity-[2] McDermott1998

7 yearsM-Nasal cavity Sphenoid sinusPPB, multiple recurrences[2] McDermott1998

4 monthsM13 yearsNasal cavityIntracranial extension[3] Kato1999

0 daysM5 yearsNasal cavity
Sphenoiod sinus
Ethmoid sinus
Orbital compression[4] Hsueh2001

9 monthsM9 monthsNasal cavity-[4] Hsueh2001

16 yearsM8 monthsNasal cavity3-month history[5] Alrawi M2003

5 monthsM-Nasal cavityOrbital compression[6] Kim B2004

11 yearsM-Nasal cavity Ethmoid sinus8-month history[7] Norman ES2004

1 yearM-Nasal cavityOrbital extension
Residual tumor
[8] Shet T2004

11 yearsM-Nasal cavity Ethmoid sinus-[9] Ozolek JA2005

17 yearsF-Nasal cavity-[9] Ozolek JA2005

25 yearsM-Nasal cavity Maxillary sinusBilateral NCMH
Intracranial aneurysms
[9] Ozolek JA2005

69 yearsF-Nasal cavity Ethmoid sinus-[9] Ozolek JA2005

11 yearsM2 monthsNasal cavity-[10] Low SE2006

15 yearsF6 monthsNasal cavityBilateral NCMH
[11] Johnson C2007

7 monthsM18 monthsNasal cavityOrbital compression[12] Silkiss RZ2007

12 monthsM-Nasal cavityOrbital compression[13] Finitsis S2009

19 monthsM10 monthsNasal cavityIntracranial, orbital extension[14] Kim JE2009

2 cases previously reported, both with PPB, multiple recurrences[15] Priest JR2010

10 yearsF21 monthsNasal cavityBilateral NCMH
[15] Priest JR2010

11 yearsM4 monthsNasal cavityPPB[15] Priest JR2010

11 yearsM--PPB[16] Behery RE2012

8 yearsM6 monthsSphenoid sinus Ethmoid sinus4-month history[17] Uzomefuna2012

14 yearsM4 yearsNasal cavity Maxillary sinus-[18] Cho YC2013

23 yearsM3 monthsNasal cavity Ethmoid SinusOrbital extension[19] Li GY2013

40 yearsF-Nasal cavity Ethmoid Sinus
Maxillary sinus
Malignant transformation Recurrence[20] Li Y2013

9 monthsF-Nasal cavity
Maxillary sinus
Orbital compression[21] Moon S2014

14 yearsM-Nasal cavityBilateral NCMH
[22] Obidan AA2014

6 weeksF10 monthsNasal cavity-[23] Wang T2014

5 yearsM3 yearsNasal cavity
Ethmoid sinus
4-year history[23] Wang T2014

10 monthsM18 monthsNasal cavity6-month history[24] Lee CH2015

49 yearsM2 years
4 years (phone)
Nasal cavity5-year history[1] Mason AK2015

Systematic review[1] Mason AK2015

5 yearsM-Nasal cavityPrevious rhabdomyosarcoma in remission[25] Avci H2016

13 yearsF12 monthsNasal cavity6-month history[26] Unal A2016

3 yearsM3 yearsNasal cavity-[27] Nakaya M2017

Index. Cases older than 1 year of age at presentation. Bilateral/cases associated with pleuropulmonary blastoma.

Our case would lend support to extending the age range for NCMH and considering it in the differential diagnosis of all sinonasal region tumors, irrespective of age, and location in the head and neck region. Despite primarily being a benign lesion, these tumors can present with areas of necrosis and local destruction, including bony invasion. The tumors can be aggressive appearing on imaging, extending into bony structures, including the cranium and/or the orbital cavity, which should not lead away from the diagnosis of this benign lesion. Detailed CT or preferably MRI prior to surgical excision should be performed.

NCMH has been associated with development of pleuropulmonary blastoma (PPB) during infancy. A recent [28] report highlighted the association of NCMH and PPB with DICER1 mutation and various associated entities such as lung cysts, cystic nephroma, renal sarcoma, Wilms tumor, thyroid hyperplasia, and CNS tumors. NCMH in isolation however is a benign lesion with follow-up in patients up to 16 years after excision, except for one reported case with malignant transformation in the literature [20]. Etiologically, it would make sense that cases in adults, such as ours, represent a tissue response to insult, such as chronic sinusitis rather than an inborn germline error (such as a DICER1 mutation).

Whether the presentation of a NCMH at a later age predisposes to malignant transformation due to the long-standing nature of the lesion is up for debate. It could represent a somatic DICER1 mutation rather than a germline mutation, causing the hamartoma to form later in age. Longer follow-up results from the adult cases and routine genetic testing in all NCMH will help provide an answer to these questions.

3. Conclusion

We report an unusual case of NCMH eroding the right maxillary sinus of a 70-year-old female. Although, NCMH is a rare entity with predilection for pediatric age groups, it is important to consider NCMH in the differential diagnosis of nasal/sinonasal masses in adult patients in order to avoid diagnostic errors.

Conflicts of Interest

The authors declare that there are no conflicts of interest regarding the publication of this paper.


  1. K. A. Mason, A. Navaratnam, E. Theodorakopoulou, and P. G. Chokkalingam, “Nasal Chondromesenchymal Hamartoma (NCMH): A systematic review of the literature with a new case report,” Journal of Otolaryngology - Head and Neck Surgery, vol. 44, no. July, 2015. View at: Google Scholar
  2. M. B. McDermott, T. B. Ponder, and L. P. Dehner, “Nasal chondromesenchymal hamartoma: An upper respiratory tract analogue of the chest wall mesenchymal hamartoma,” The American Journal of Surgical Pathology, vol. 22, no. 4, pp. 425–433, 1998. View at: Publisher Site | Google Scholar
  3. K. Kato, R. Ijiri, Y. Tanaka, M. Hara, and K. Sekido, “Nasal chondromesenchymal hamartoma of infancy: The first Japanese case report,” Pathology International, vol. 49, no. 8, pp. 731–736, 1999. View at: Publisher Site | Google Scholar
  4. C. Hsueh, “Nasal chondromesenchymal hamartoma in children: report of 2 cases with review of the literature,” Archives of Pathology & Laboratory Medicine, vol. 125, no. 3, p. 400, 2001. View at: Google Scholar
  5. M. Alrawi, M. McDermott, D. Orr, and J. Russell, “Nasal chondromesynchymal hamartoma presenting in an adolescent,” International Journal of Pediatric Otorhinolaryngology, vol. 67, no. 6, pp. 669–672, 2003. View at: Publisher Site | Google Scholar
  6. B. Kim, S.-H. Park, H. S. Min, J. S. Rhee, and K. C. Wang, “Nasal chondromesenchymal hamartoma of infancy clinically mimicking meningoencephalocele,” Pediatric Neurosurgery, vol. 40, no. 3, pp. 136–140, 2004. View at: Publisher Site | Google Scholar
  7. E. S. Norman, S. Bergman, and J. K. Trupiano, “Nasal chondromesenchymal hamartoma: Report of a case and review of the literature,” Pediatric and Developmental Pathology, vol. 7, no. 5, pp. 517–520, 2004. View at: Publisher Site | Google Scholar
  8. T. Shet, A. Borges, C. Nair, S. Desai, and R. Mistry, “Two unusual lesions in the nasal cavity of infants - A nasal chondromesenchymal hamartoma and an aneurysmal bone cyst like lesion - More closely related than we think?” International Journal of Pediatric Otorhinolaryngology, vol. 68, no. 3, pp. 359–364, 2004. View at: Publisher Site | Google Scholar
  9. J. A. Ozolek, “Nasal chondromesenchymal hamartoma in older children and adults: series and immunohistochemical analysis,” Archives of Pathology & Laboratory Medicine, vol. 129, no. 11, pp. 1444–50, 2005. View at: Google Scholar
  10. S. E. Low, R. K. Sethi, E. Davies, and J. S. Stafford, “Nasal chondromesenchymal hamartoma in an adolescent,” Histopathology, vol. 49, no. 3, pp. 321–323, 2006. View at: Publisher Site | Google Scholar
  11. C. Johnson, U. Nagaraj, J. Esguerra, D. Wasdahl, and D. Wurzbach, “Nasal chondromesenchymal hamartoma: Radiographic and histopathologic analysis of a rare pediatric tumor,” Pediatric Radiology, vol. 37, no. 1, pp. 101–104, 2007. View at: Publisher Site | Google Scholar
  12. R. Z. Silkiss, S. S. Mudvari, and D. Shetlar, “Ophthalmologic presentation of nasal chondromesenchymal hamartoma in an infant,” Ophthalmic Plastic & Reconstructive Surgery, vol. 23, no. 3, pp. 243-244, 2007. View at: Publisher Site | Google Scholar
  13. S. Finitsis, C. Giavroglou, S. Potsi et al., “Nasal chondromesenchymal hamartoma in a child,” CardioVascular and Interventional Radiology, vol. 32, no. 3, pp. 593–597, 2009. View at: Publisher Site | Google Scholar
  14. J.-E. Kim, H.-J. Kim, H. K. Ji, Y.-H. Ko, and S.-K. Chung, “Nasal chondromesenchymal hamartoma: CT and MR imaging findings,” Korean Journal of Radiology, vol. 10, no. 4, pp. 416–419, 2009. View at: Publisher Site | Google Scholar
  15. J. R. Priest, G. M. Williams, W. A. Mize, L. P. Dehner, and M. B. McDermott, “Nasal chondromesenchymal hamartoma in children with pleuropulmonary blastoma-A report from the International Pleuropulmonary Blastoma Registry registry,” International Journal of Pediatric Otorhinolaryngology, vol. 74, no. 11, pp. 1240–1244, 2010. View at: Publisher Site | Google Scholar
  16. R. El Behery, J. Bedrnicek, A. Lazenby et al., “Translocation t(12;17)(q24.1;q21) as the sole anomaly in a nasal chondromesenchymal hamartoma arising in a patient with pleuropulmonary blastoma,” Pediatric and Developmental Pathology, vol. 15, no. 3, pp. 249–253, 2012. View at: Publisher Site | Google Scholar
  17. V. Uzomefuna, F. Glynn, J. Russell, and M. McDermott, “Nasal chondromesenchymal hamartoma with no nasal symptoms,” BMJ Case Reports, 2012. View at: Google Scholar
  18. Y. C. Cho, I. Y. Sung, J. H. Son, and R. Ord, “Nasal chondromesenchymal hamartoma: Report of a case presenting with intraoral signs,” Journal of Oral and Maxillofacial Surgery, vol. 71, no. 1, pp. 72–76, 2013. View at: Publisher Site | Google Scholar
  19. G.-Y. Li, B. Fan, and Y.-Y. Jiao, “Endonasal endoscopy for removing nasal chondromesenchymal hamartoma extending from the lacrimal sac region,” Canadian Journal of Ophthalmology, vol. 48, no. 2, pp. e22–e23, 2013. View at: Publisher Site | Google Scholar
  20. M. Sharif and Abdul Jawad, “Interacting generalized dark energy and reconstruction of scalar field models,” Modern Physics Letters A, vol. 28, no. 38, Article ID 1350180, 15 pages, 2013. View at: Publisher Site | Google Scholar
  21. S. H. Moon and M. M. Kim, “Nasal chondromesenchymal hamartoma with incomitant esotropia in an infant: A case report,” Canadian Journal of Ophthalmology, vol. 49, no. 1, pp. e30–e32, 2014. View at: Publisher Site | Google Scholar
  22. A. A. Obidan and M. M. Ashoor, “Nasal chondromesenchymal hamartoma in an adolescent with pleuropulmonary blastoma,” Saudi Medical Journal, vol. 35, no. 8, pp. 876–878, 2014. View at: Google Scholar
  23. T. Wang, W. Li, X. Wu et al., “Nasal chondromesenchymal hamartoma in young children: CT and MRI findings and review of the literature,” World Journal of Surgical Oncology, vol. 12, no. 1, p. 257, 2014. View at: Publisher Site | Google Scholar
  24. C. H. Lee, Y. H. Park, J. Y. Kim, and J. H. Bae, “Nasal chondromesenchymal hamartoma causing sleep-disordered breathing in an infant,” International Journal of Clinical and Experimental Pathology, vol. 8, no. 8, pp. 9643–9646, 2015. View at: Google Scholar
  25. H. Avcı, Ş. Çomoğlu, E. Öztürk, B. Bilgiç, and Ö. E. Kıyak, “Nasal chondromesenchymal hamartoma: a rare nasal benign tumor,” Kulak burun bogaz ihtisas dergisi : KBB = Journal of ear, nose, and throat, vol. 26, no. 5, pp. 300–303, 2016. View at: Publisher Site | Google Scholar
  26. A. Ünal, R. O. Kum, Y. Avcı, and D. T. Ünal, “Nasal chondromesenchymal hamartoma, a rare pediatric tumor: Case report,” The Turkish Journal of Pediatrics, vol. 58, no. 2, pp. 208–211, 2016. View at: Publisher Site | Google Scholar
  27. M. Nakaya, S. Yoshihara, A. Yoshitomi, and S. Baba, “Endoscopic endonasal excision of nasal chondromesenchymal hamartoma with intracranial extension,” European Annals of Otorhinolaryngology, Head and Neck Diseases, vol. 134, no. 6, pp. 423–425, 2017. View at: Publisher Site | Google Scholar
  28. D. A. Hill, J. Ivanovich, J. R. Priest et al., “DICER1 mutations in familial pleuropulmonary blastoma,” Science, vol. 325, no. 5943, p. 965, 2009. View at: Publisher Site | Google Scholar

Copyright © 2018 Kanish Mirchia and Rana Naous. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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