Suprasellar Ganglioglioma: Expanding the Differential Diagnosis

Figure 2

(a) The tumor has a fibrillary glial background with occasional Rosenthal fibers (arrows). H&E stained section, 40x original magnification

(b) Multiple eosinophilic granular bodies are present within the glial areas (arrows) H&E stained section, 100x original magnification

(c) Multiple dysplastic neurons are seen in a cluster, and binucleate forms are readily identified (arrows). H&E stained section, 200x original magnification

(d) Granular immunoreactivity for Synaptophysin highlights dysplastic neurons, some of which are binucleate (arrows). Immunohistochemistry for Synaptophysin, 200x original magnification

(e) Glial fibrillary acidic protein immunoreactive cells and processes are seen throughout the tumor. Immunohistochemistry for GFAP, 100x original magnification

(f) Some neurons are also positive for CD34 (arrows). Immunohistochemistry for CD34 100x original magnification