Fibrous Extracellular Spheroids in an Endoscopic Ultrasound-Guided Pancreatic Fine Needle Aspiration Correlating to a Gyriform Pancreatic Endocrine Tumor with a Unique Cobblestone Pavement Growth Pattern

<div>(a) Diffuse granular cytoplasmic immunoreactivity is present in the ribbons of lesional epithelial cells between fibrous spheroids (Chromogranin A immunohistochemistry, 400X).  (b) Diffuse and strong homogenous cytoplasmic immunoreactivity is confirmed in the epithelial cells (Synaptophysin immunohistochemistry, 400X). (c) Very rare epithelial nuclei (&lt;3% of lesional cells) show immunoreactivity with the proliferation marker (Ki-67 immunohistochemistry, 400X).</div>

Case Reports in Pathology

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Figure 11

Figure 11: Fibrous Extracellular Spheroids in an Endoscopic Ultrasound-Guided Pancreatic Fine Needle Aspiration Correlating to a Gyriform Pancreatic Endocrine Tumor with a Unique Cobblestone Pavement Growth Pattern 

Figure 11 | Fibrous Extracellular Spheroids in an Endoscopic Ultrasound-Guided Pancreatic Fine Needle Aspiration Correlating to a Gyriform Pancreatic Endocrine Tumor with a Unique Cobblestone Pavement Growth Pattern 