Differentiated-Type Intraepithelial Neoplasia-Like Lesion Associated with Squamous Cell Carcinoma of the Anus: A Case Report with Molecular Profile

Figure 4

Microscopic and immunohistochemical aspects of 2nd excision. At low power view, the epithelium appeared thickened with parakeratosis and elongated rete ridges (a). At high power view, note the disorderly basal cell layer, prominent intercellular bridges, prominent nucleoli, and mitosis (b). Immunoreactivity of p53 appeared limited to the basal and suprabasal layers of the epithelium, with weak to moderate intensity (c). Immunoreactivity of p53 in adjacent “normal” epithelium (d).

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