Case Report

Composite Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and T-Prolymphocytic Leukemia Presenting with Lymphocytosis, Skin Lesions, and Generalized Lymphadenopathy

Table 1

Summary of the most important clinical and pathologic features of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and T-cell prolymphocytic leukemia (T-PLL) as seen in our patient. Of note, these features do not necessarily represent the most common features of CLL/SLL or T-PLL.

FeaturesCLL/SLLT-PLL

Initial presentationIncidental enlargement of LN
(pelvic LN dissection)
Generalized and constitutional
symptoms

ImmunophenotypeCD20+, CD5+, CD19+, CD23+, CD200+CD3+, CD5+, CD7+, CD4+, CD8+, CD26+

TCL1 immunostainNegativePositive

IGH/T-cell gene rearrangementsClonal IGHClonal TRB, TRG

Chromosomal and gene abnormalitiesTrisomy 12
ATM deletion
inv(14)(q11.2q32)
ATM deletion,
TCL1 rearrangement

NGS analysisNM_000051.3(ATM):c.8078_8080del p.A2693del
NM_002468.4(MYD88):c.794T>C p.L265P