Carcinosarcoma of the Gallbladder with Chondrosarcomatous Differentiation and Intracytoplasmic Eosinophilic Hyaline Globules (Thanatosomes): A Report of a Case and Review of the Literature

Figure 2

(a) Solid nests of malignant epithelial cells surrounded by malignant mesenchymal cells with pleomorphic nuclei and mitotic figures. H&E x200. (b) Solid nest of malignant epithelial cells with squamoid features surrounded by pleomorphic sarcomatous cells with bizarre nuclei. Note the presence of three atypical mitotic figures. H&Ex400. (c) An island of malignant cartilage with malignant chondrocytes featuring pleomorphic large nuclei, surrounded by spindly sarcomatous cells. H&E x200. (d) Island of malignant cartilage with adjacent pleomorphic sarcomatous cells containing eosinophilic hyaline globules 9Thanatosomes). H&E x200. (e) Intracytoplasmic eosinophilic hyaline globules (Thanatosomes) within the cytoplasm of sarcomatous cells. H&E x400. (f) Numerous eosinophilic hyaline globules (Thanatosomes), some are extruded into adjacent stroma. H&E x400.

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