Primary Intraosseous Synovial Sarcoma with Molecular Confirmation: Expanding and Clarifying the Spectrum of This Rare Neoplasm

Table 2

Reported cases of primary intraosseous synovial sarcoma without molecular and/or cytogenetic confirmation of the diagnosis.

Author	Year	No. cases	Age	Sex	Anatomic site	Extraosseous component	Morphology	Clinical management	Clinical follow-up
Rose et al.	1982	1	16	F	Distal femur	No	Biphasic	Subtrochanteric amputation	NA
Nakajo et al.	2005	1	86	M	Sternum	Yes	Monophasic	NA	NA
Tilakaratne et al.	2006	1	29	F	Mandible ramus	No	Monophasic	Adjuvant XRT	NED 2 years
Tao et al.	2011	1	20	F	Posterior mandible	No	Monophasic	Extensive mandibulectomy; adjuvant XRT	NED 6 months
Khalili et al.	2012	1	76	M	Posterior mandible	No	Monophasic	Lymph node metastases at the time of diagnosis	DOD at 2 mo. postdiagnosis
Zulkarnaen et al.	2012	1	57	M	Proximal femur	Yes	Biphasic	Neoadjuvant chemotherapy; wide excision; adjuvant chemotherapy	Pulmonary metastasis; DOD
Kim et al.	2013	1	17	M	C3 vertebra	No	Monophasic	NA	NA
Bansal et al.	2015	1	16	F	Mandible	Yes	Monophasic	NA	NA
Liu et al.	2015	15	14-62y	5M, 10F	Maxilla (7); Mandible (8)	NA	6 biphasic, 9 monophasic	Lymph node metastases in 1 patient; adjuvant XRT in 9 patients; adjuvant chemotherapy in 6 patients	6 patients with local recurrence (LR); 1 patient with pulmonary metastasis; 4 patients with LR DOD
Cardosa et al.	2016	1	56	F	Scapula	Yes	Monophasic	Neoadjuvant chemotherapy; en bloc resection	Subsequent lymph node metastases; excision and adjuvant XRT
Deyong et al.	2016	2	NA	NA	NA	NA	NA	NA	NA

Total cases: 26. FISH molecular testing was performed and was negative for an SYT gene rearrangement. Abbreviations: F: female; M: male; NA: not applicable (not reported); XRT: radiation therapy; NED: no evidence of disease; DOD: dead of disease.