Metastasis of Uterine Leiomyosarcoma to the Breast: Medical and Histopathological Criteria

Figure 2

(a) Hematoxylin-eosine from the biopsy material shows solid nests of spindle cells containing fascicular growth pattern, tumor cell merge with blood vessel walls, palisading of spindle cells with eosinophilic fibrillary cytoplasm, focal granularity, and large nuclei cigar-shaped blunt-ended with variable atypia. (b) High mitotic activity is seen with Ki67. (c–f) Tumor cells were positive for smooth muscle actin, caldesmon, and vimentin indicating a nonbreast tissue origin rather than indicating a smooth muscle origin. (d) Tumor cells were negative for CKMNF116.

(a)

(b)

(c)

(d)

(e)

(f)