Fifteen-Year Follow-Up of a Patient with Acinar Cystic Transformation of the Pancreas and Literature Review

Figure 3

Microscopic images of ACT. Boxed areas are shown in a higher magnification on the right side of the corresponding picture. (a) ACT in the resection specimen consists of multiple variable-sized cysts (H&E, 20x magnification). (b) The lesion is lined by cells with acinar differentiation which have apical eosinophilic cytoplasmic granules and uniform nuclei. Cytologic atypia and mitotic figures are absent (H&E, 400x magnification). (c) Prior intraoperative biopsy of the cyst wall (H&E, 20x magnification). (d) The prior intraoperative biopsy shows similar epithelial lining to that seen in the resection specimen (H&E, 400x magnification). (e) The lining cells have coarsely granular apical cytoplasmic staining for trypsin (400x magnification). (f) The lining cells have strong and diffuse cytoplasmic staining for CK7 (400x magnification).

(a)

(b)

(c)

(d)

(e)

(f)