Plasmablastic Lymphoma Associated with Adjacent Mature Plasma Cell Population Exhibiting Opposite Light Chain Restriction

Figure 5

Immunoglobulin heavy chain clonality testing by next-generation sequencing. (a) Results from the plasmablastic lymphoma demonstrating two distinct peaks consistent with a biallelic rearranged clone. (b) Results from the mature plasma cell neoplasm with inclusive results due to a low number of reads, but demonstrating an oligoclonal pattern with low-level detection of the biallelic clone found in the PBL population.

(a) Plasmablastic lymphoma biallelic rearranged clone

(b) Mature plasma cell population