Plasmablastic Lymphoma Associated with Adjacent Mature Plasma Cell Population Exhibiting Opposite Light Chain Restriction

Table 1

Next-generation sequencing targeted panel (596 gene panel). (a) Plasmablastic lymphoma. (b) Mature plasma cell neoplasm.

(a) Plasmablastic lymphoma

Gene symbol	Protein change	Allelic fraction
FANCC	c.1243G>A p.A415T missense variant	43.00%
STAT3	c.1243G>A p.E415K missense variant	38.90%
NF1	c.2278_2280del p.M760del Inframe deletion	38.50%
CD274 (PD-L1)	c.238A>G p.S80G missense variant	34.30%
KDM6A	c.1683+5_1683+6del splice region variant	20.10%
DOT1L	c.1905G>T p.R635S missense variant	18.40%
RB1	c.295T>G p.W99G missense variant	14.70%
SMARCE1	c.1079G>A p.G360D missense variant	13.90%
MAF	c.1023G>C p.R341S missense variant	7.60%
PAX3	c.499G>A p.E167K missense variant	6.10%

(b) Mature plasma cell neoplasm

Gene symbol	Protein change	Allelic fraction
FANCC	c.1243G>A p.A415T missense variant	47.50%
STAT3	c.1243G>A p.E415K missense variant	14.60%
ETV1	c.593C>T p.P198L missense variant	9.90%
NF1	c.2278_2280del p.M760del Inframe deletion	9.50%
CIC	c.7517del p.P2506fs Frameshift	9.40%
PRSS1	c.32C>A p.A11E missense variant	7.50%