Case Report
Plasmablastic Lymphoma Associated with Adjacent Mature Plasma Cell Population Exhibiting Opposite Light Chain Restriction
Table 1
Next-generation sequencing targeted panel (596 gene panel). (a) Plasmablastic lymphoma. (b) Mature plasma cell neoplasm.
(a) Plasmablastic lymphoma |
| Gene symbol | Protein change | Allelic fraction |
| FANCC | c.1243G>A p.A415T missense variant | 43.00% | STAT3 | c.1243G>A p.E415K missense variant | 38.90% | NF1 | c.2278_2280del p.M760del Inframe deletion | 38.50% | CD274 (PD-L1) | c.238A>G p.S80G missense variant | 34.30% | KDM6A | c.1683+5_1683+6del splice region variant | 20.10% | DOT1L | c.1905G>T p.R635S missense variant | 18.40% | RB1 | c.295T>G p.W99G missense variant | 14.70% | SMARCE1 | c.1079G>A p.G360D missense variant | 13.90% | MAF | c.1023G>C p.R341S missense variant | 7.60% | PAX3 | c.499G>A p.E167K missense variant | 6.10% |
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(b) Mature plasma cell neoplasm |
| Gene symbol | Protein change | Allelic fraction |
| FANCC | c.1243G>A p.A415T missense variant | 47.50% | STAT3 | c.1243G>A p.E415K missense variant | 14.60% | ETV1 | c.593C>T p.P198L missense variant | 9.90% | NF1 | c.2278_2280del p.M760del Inframe deletion | 9.50% | CIC | c.7517del p.P2506fs Frameshift | 9.40% | PRSS1 | c.32C>A p.A11E missense variant | 7.50% |
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