Acute Coronary Syndrome in Acute Myeloid Leukemia with Maturation Accompanying Megakaryocytic Differentiation

Figure 3

The heart involved by leukemic cells ((a) cut surface of the heart after formalin fixation; (b) H&E, inset: high-powered view; (c) MPO; (d) CD61). Grossly, the subendocardial myocardium circumferentially appears dark-colored. Microscopically, the MPO-positive leukemic blasts invade both the myocardium and endocardium. CD61-positive megakaryocytic cells are distributed in the endocardium. The inset demonstrates high-powered H&E morphology of a subendocardial located megakaryocyte. The infiltrating blasts replace the cardiomyocytes. Neither granulation tissue reaction nor fibrosis is seen in the involved myometrium.

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