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| (i) Acute myeloid leukemia (FAB M1) with maturation accompanying megakaryocytic differentiation |
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| (a) No treatment given (clinical course: 25 days) |
| (b) Marker expression: CD34+, CD117+ (c-kit), MPO+, CD42b-, CD61-, CD10-, TdT-, CD3-, CD20-, and CD79a- |
| (c) Infiltration of leukemic blasts |
| (1) Leukemic bone marrow (100%) |
| (2) Liver (1,000 g) |
| (3) Spleen (200 g) |
| (4) Lymph nodes (max. 15 mm) |
| (5) Serosal membranes: (ascites 70 mL; pleura effusion left 1,100 mL, right: unmeasurable; pericardial effusion 80 mL) |
| (6) Lung (multifocal, severe; left 330 g, right 420 g) |
| (7) Subendocardial myometrium and endocardium (heart weight 410 g) |
| (8) Lard-like blood clot in the heart, aorta, and pleural and pericardial cavities |
| (9) Leukemic infiltration to the kidney (left 250 g, right 190 g), adrenal glands (left 10 g, right 5 g), , vermiform appendix, prostate, and seminal vesicles |
| (d) Megakaryocytic differentiation seen in the bone marrow, lymph nodes, liver, and endocardium |
| (ii) Secondary pneumonia (severe): organizing pneumonia and aspiration pneumonia |
| Direct cause of death: respiratory failure due to leukemic infiltration to the lung and pleura |
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