Primary Angiosarcoma of the Thyroid in an Asian Woman: A Case Report with Review of the Literature

Figure 1

(a) The tumor is hemorrhagic and composed of ramifying and intercommunicating vascular spaces with infiltration into adjacent thyroid tissue (Mag.100x). (b) Those tumor cells have large epithelioid and pleomorphic nuclei with clumped chromatin and prominent basophilic nucleoli, and abundant eosinophilic cytoplasm exhibiting occasional intracytoplasmic lumina with identifiable erythrocytes (Mag.400x). (c) Diffuse membranous and cytoplasmic immunoreactivity for CD31 (Mag.200x). (d) Faint and focal expression of CD34 (Mag.200x). (e) Diffuse nuclear staining for ERG (Mag.200x). (f) Faint and focal cytoplasmic immunoreactivity for Factor VIII-associated antigen (Mag.200x). (g) Negative staining for pancytokeratin in lesional cells (Mag.200x). (h) No expression for thyroglobulin (Mag.200x).

(a) (×100)

(b) (×400)

(c) CD31

(d) CD34

(e) ERG

(f) Factor VIII

(g) CK

(h) TG