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No. | Authors year [reference] | Age/sex | NF1 | Location | Divergent differentiation components in MPNST | Treatment and outcome |
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1 | Després et al. 1973 [5] | 38/F | Yes | Sciatic nerve | RMS and benign glands | Surgery; recurred at 13 months; DOD at 19 months |
2 | Warner et al. 1983 [6] | 29/M | Yes | Thigh | RMS and benign glands | Surgery; no follow-up data available |
3 | Daimaru et al. 1984 [7] | 27/F | Yes | Buttock | RMS and benign glands | Surgery; DOD after 4 months |
4 | Christensen et al. 1988 [8] | NAD | NAD | NAD | RMS and benign glands | NAD |
5 | Christensen et al. 1988 [8] | NAD | NAD | NAD | RMS, osteosarcoma, and benign glands | NAD |
6 | Ho and Che 1989 [9] | 14/F | Yes | Left sciatic nerve | RMS and benign glands of intestinal type epithelium | Surgical excision of the tumor (); no follow-up data available |
7 | Wong et al. 1991 [10] | 39/M | No | Thorax, overlying T1-T4 | RMS and malignant glands | Surgery, radiotherapy, and chemotherapy; recurred at 1 year; DOD at 15 months |
8 | Rose et al. 1992 [11] | 34/M | Yes | Brachial plexus | RMS and glands with moderate nuclear atypia | Surgery, radiotherapy, and chemotherapy; recurred at 14 months; DOD at 18 months |
9 | Woodruff and Christensen 1993 [12] | 20/F | Yes | Right side of neck, associated with plexiform neurofibroma | RMS, chondrosarcoma, osteosarcoma, and benign glands | Subtotal surgical resection; DOD after 3 months |
10 | Ordonez 1998 [13] | 28/M | No | Right lumbar area, overlying L5 | RMS and glands lined by a single layer of columnar cells or by multiple layers of cuboidal cells having marked nuclear atypia | Surgery, radiotherapy, and chemotherapy (Adriamycin); DOD after 33 months |
11 | Karpuz et al. 2000 [14] | 52/M | No | Chest wall | RMS and benign glands | Surgery; recurred after 5 years |
12 | Huang et al. 2003 [15] | 24/M | No | Thigh | RMS and malignant glands | Surgery; lung metastasis after 5 months; DOD after 6 months |
13 | Guo et al. 2012 [16] | 79/M | NAD | Thigh | RMS, glands, lipoblasts, and ganglion cells | Surgery, radiotherapy, and chemotherapy; recurred after10 months, without metastasis |
14 | Thway et al. 2015 [17] | 40/M | No | Mediastinum | RMS and benign glands | Surgery; brain metastasis after 15 months; transferred for palliation at 24 months |
15 | AlAli and Amr 2020 current case | 26/M | No | Elbow, radial nerve | RMS and malignant glands | Surgery, radiotherapy, and chemotherapy; no recurrence or metastases for 10 years |
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