Primary Signet Ring Cell/Histiocytoid Carcinoma of the Eyelid: Clinicopathologic Analysis with Evaluation of the E-Cadherin/<i>β</i>-Catenin Complex and Associated Genetic Alterations

<div>Case 3. Orbital exenteration. Circumferential sectioning of the eyelids and soft tissue allowed for mapping tumor extension which is nearly 360° (tumor spread = red area). Grossly, only slight firmness was present in the temporal/lacrimal gland area. Histopathologically, the tumor involves the dermis, palpebral conjunctiva, and periorbital soft tissue (arrow).</div>

Case Reports in Pathology

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Figure 1: Primary Signet Ring Cell/Histiocytoid Carcinoma of the Eyelid: Clinicopathologic Analysis with Evaluation of the E-Cadherin/<i>β</i>-Catenin Complex and Associated Genetic Alterations 

Figure 1 | Primary Signet Ring Cell/Histiocytoid Carcinoma of the Eyelid: Clinicopathologic Analysis with Evaluation of the E-Cadherin/β-Catenin Complex and Associated Genetic Alterations 