Primary Signet Ring Cell/Histiocytoid Carcinoma of the Eyelid: Clinicopathologic Analysis with Evaluation of the E-Cadherin/<i>β</i>-Catenin Complex and Associated Genetic Alterations

<div>Case 1: (a) CT of maxillofacial area disclosing enhancement along the right infraorbital region (arrow); (b) multifocal cords of signet ring cells infiltrating dermis and directly associated with eccrine dermal ducts (H&amp;E 10x). Inset disclosing single dyshesive signet ring cells infiltrating connective tissue (H&amp;E 20x). Case 2: (c) MRI of the orbit, face, and neck depicting a right anterior mass adjacent to the nasolacrimal duct (arrow); (d) neoplastic cells infiltrating connective tissue and disclosing perineural invasion (inset: 20x).</div>

Case Reports in Pathology

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Figure 2: Primary Signet Ring Cell/Histiocytoid Carcinoma of the Eyelid: Clinicopathologic Analysis with Evaluation of the E-Cadherin/<i>β</i>-Catenin Complex and Associated Genetic Alterations 

Figure 2 | Primary Signet Ring Cell/Histiocytoid Carcinoma of the Eyelid: Clinicopathologic Analysis with Evaluation of the E-Cadherin/β-Catenin Complex and Associated Genetic Alterations 