Primary Signet Ring Cell/Histiocytoid Carcinoma of the Eyelid: Clinicopathologic Analysis with Evaluation of the E-Cadherin/β-Catenin Complex and Associated Genetic Alterations

Figure 3

Case 3: (a) MRI depicting an infiltrative lesion involving pre- and postseptal regions of the left upper and lower eyelids (arrow); (b) tarsus diffusely infiltrated by neoplastic cells (H&E 4x). Inset: higher magnification of cords of neoplastic cells infiltrating skeletal muscle (20x). Case 4: (c) CT scan shows enhancing and infiltrative mass along the inferomedial aspect of the left anterior orbit; (d) panoramic view shows neoplastic cells forming a mass lesion adjacent to the punctum (arrowhead) and infiltrating caruncle (H&E). Inset: higher magnification depicting tumor cells with vesicular nuclei, large nucleoli, and eosinophilic cytoplasm with intracytoplasmic vacuolization (H&E 20x).

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