Primary Signet Ring Cell/Histiocytoid Carcinoma of the Eyelid: Clinicopathologic Analysis with Evaluation of the E-Cadherin/β-Catenin Complex and Associated Genetic Alterations

<div>Case 1: (a) neoplastic cells show loss of E-cadherin expression (4x); (b) weak heterogeneous membranous staining for β-catenin is seen focally (20x); (c) low cytoplasmic expression of Src (10x). Case 2: (d) tumor cells depicting loss of E-cadherin expression (4x); (e) heterogeneous, incomplete membranous staining for β-catenin is present (10x); (f) focal low cytoplasmic staining for Src in less than 25% of tumor cells (20x).</div>

Case Reports in Pathology

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Figure 4: Primary Signet Ring Cell/Histiocytoid Carcinoma of the Eyelid: Clinicopathologic Analysis with Evaluation of the E-Cadherin/β-Catenin Complex and Associated Genetic Alterations

Figure 4 | Primary Signet Ring Cell/Histiocytoid Carcinoma of the Eyelid: Clinicopathologic Analysis with Evaluation of the E-Cadherin/β-Catenin Complex and Associated Genetic Alterations 