Association of Sweet's Syndrome and Systemic Lupus Erythematosus

Table 1

Demographic and clinical characteristics of SLE patients at time of presentation with Sweet’s.

Patient	Gender	Age	Race/ethnicity	Clinical manifestations of SLE at time of Sweet's presentation	Serologies	Histopathology	Treatment	Response
1	Female	26	Asian	Oral ulcers, Raynaud’s, hemolytic anemia	ANA, anti-Sm, anti-Sm/RNP	Sparse interstitial neutrophilic dermatitis	Prednisone 40 mg, hydroxychloroquine	Responsive to treatment
2	Female	23	Asian	Malar rash, pericarditis, arthritis, hemolytic anemia	ANA, anti-dsDNA, anti-La,	Neutrophilic dermatitis	Prednisone	Responsive to treatment
3	Male	23	Asian		ANA, dsDNA	Neutrophilic dermatitis	Hydroxychloroquine, prednisone	Responsive to treatment
Goette 1985 [7]	Male	67	NA	Arthritis, malar, and discoid rashes, leukopenia, thrombocytopenia	ANA	Prominent dermal edema, extensive infiltration with intact and karyorrhectic PMNs	Prednisone 30–40 mg, quinacrine hydrochloride 100 mg	Responsive to treatment
Choi and Chung, 1999 [5]	Female	13	Asian	Malar rash, oral ulcers, leukopenia, thrombocytopenia, nephritis	ANA, anti-Sm, anti-dsDNA	Neutrophilic dermatosis	Pulse methylprednisolone	Responsive to treatment
Burnham and Cron, 2005 [10]	Female	14	African American	Arthritis, oral ulcer, leukopenia	ANA, anti-dsDNA, anti-Ro, anti-La, anti-SM/RNP	Marked edema of papillary dermis with early subepidermal bullae, PMNs and karyorrhexis	NA	NA
Hou et al., 2005 [8]	Female	38	Asian	Arthritis, proteinuria >0.5 mg/day,	ANA, anti-Ro, anti-La	Neutrophilic dermatosis	Prednisolone 20 mg	Responsive to treatment
Gleason et al., 2006 [9]	Female	16	NA	Arthritis, serositis, leukopenia	ANA, anti-dsDNA	Neutrophilic dermatosis	Hydroxychloroquine, prednisone	Responsive to treatment
Gleason et al., 2006 [9]	Female	35	NA	Arthritis, hematuria (lupus nephritis on prior biopsy)	ANA, anti-dsDNA, anti-Ro	Neutrophilic dermatosis	Corticosteroids, dapsone, azathioprine	Responsive to treatment
Camarillo et al., 2008 [3]	Female	9	NA	Lymphopenia, (mesangial glomerulonephritis prior)	ANA, anti-dsDNA, anti-RNP	Interstitial dermal infiltrate of histiocytelike cells, lymphocytes and segmented neutrophils and leukocytoclastic debris	Methylprednisolone, dapsone	Responsive to treatment
Fernandes et al., 2009 [6]	Male	25	NA	Leukopenia, proteinuria, malar rash	ANA, anti-Sm/RNP, anti-dsDNA	Neutrophilic dermatitis	Prednisone	Responsive to treatment
Gollol-Raju et al., 2009 [4]	Female	23	NA	Malar rash (lupus nephritis previously)	ANA	Acute inflammatory cells with overlying keratin debris, abundant neutrophilic dust	Corticosteroids	Responsive to treatment