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Case Reports in Rheumatology
Volume 2013, Article ID 637015, 7 pages
http://dx.doi.org/10.1155/2013/637015
Case Report

Behçet’s Disease and Intracardiac Thrombosis: A Report of Three Cases

1Department of Internal Medicine-Rheumatology, Ankara University, Faculty of Medicine, Akademik Yerleşke, Sıhhıye, 06100 Ankara, Turkey
2Department of Radiology, Ankara University, Faculty of Medicine, Akademik Yerleşke, Sıhhıye, 06100 Ankara, Turkey
3Department of Neurology, Ankara University, Faculty of Medicine, Akademik Yerleşke, Sıhhıye, 06100 Ankara, Turkey
4Department of Cardiology, Ankara University, Faculty of Medicine, Akademik Yerleşke, Sıhhıye, 06100 Ankara, Turkey
5Department of Internal Medicine, Ankara University, Faculty of Medicine, Akademik Yerleşke, Sıhhıye, 06100 Ankara, Turkey

Received 20 April 2013; Accepted 14 May 2013

Academic Editors: G. S. Alarcon and R. Cevik

Copyright © 2013 Nurşen Düzgün et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. Behçet, “Uber residiverende apthose durchein virus verurschte Geschwure am Mund, am Auge und an den genitalien,” Dermatol Wochenschr, vol. 105, pp. 1152–1157, 1937. View at Google Scholar
  2. J. T. Lie, “Vascular involvement in Behcet's disease: arterial and venous and vessels of all sizes,” Journal of Rheumatology, vol. 19, no. 3, pp. 341–343, 1992. View at Google Scholar · View at Scopus
  3. Y. Koç, I. Güllü, G. Akpek et al., “Vascular involvement in Behçet's disease,” The Journal of Rheumatology, vol. 19, no. 3, pp. 402–410, 1992. View at Google Scholar
  4. N. Düzgün, A. Ates, O. T. Aydintug, O. Demir, and U. Olmez, “Characteristics of vascular involvement in Behçet's disease,” Scandinavian Journal of Rheumatology, vol. 35, no. 1, pp. 65–68, 2006. View at Google Scholar
  5. G. Geri, B. Wechsler, D. L. Thi Huong et al., “Spectrum of cardiac lesions in Behçet disease: a series of 52 patients and review of the literature,” Medicine, vol. 91, no. 1, pp. 25–34, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. S. Lakhanpal, K. Tani, J. T. Lie, K. Katoh, Y. Ishigatsubo, and T. Ohokubo, “Pathologic features of Behcet's syndrome: a review of Japanese autopsy registry data,” Human Pathology, vol. 16, no. 8, pp. 790–795, 1985. View at Google Scholar · View at Scopus
  7. M. Marzban, M. H. Mandegar, A. Karimi et al., “Cardiac and great vessel involvement in Behçet’s disease,” Journal of Cardiac Surgery, vol. 23, no. 6, pp. 765–768, 2008. View at Publisher · View at Google Scholar
  8. F. Atzeni, P. Sarzi-Puttini, A. Doria, L. Boiardi, N. Pipitone, and C. Salvarani, “Behçet's disease and cardiovascular involvement,” Lupus, vol. 14, no. 9, pp. 723–726, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Hamzaoui, N. Bel Feki, A. Brahem Sfaxi et al., “Chest pain in patients with under undiagnosed of Behçet’s disease,” Clinical and Experimental Rheumatology, vol. 30, supplement 72, pp. S76–S79, 2012. View at Google Scholar
  10. N. Moğulkoç, M. I. Burgess, and P. W. Bishop, “Intracardiac thrombus in Behçet’s disease: a systematic review,” Chest, vol. 118, no. 2, pp. 479–487, 2000. View at Google Scholar
  11. T. Kajiya, R. Anan, M. Kameko et al., “Intracardiac thrombus, superior vena cava syndrome, and pulmonary embolism in a patient with Behçet's disease: a case report and literature review,” Heart and Vessels, vol. 22, no. 4, pp. 278–283, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. P. Hiwarkar, R. Stasi, G. Sutherland, and M. Shannon, “Deep vein and intracardiac thrombosis during the post-partum period in Behçet's disease,” International Journal of Hematology, vol. 91, no. 4, pp. 679–686, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. E. Seyahi, M. Melikoglu, C. Akman et al., “Pulmonary artery involvement and associated lung disease in Behçet disease: a series of 47 patients,” Medicine, vol. 91, no. 1, pp. 35–48, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. R. Hammami, L. Abid, F. Frikha et al., “Intracardiac thrombus in young man: don't forget Behçet’s disease,” Intern Med, vol. 51, no. 14, pp. 1865–1867, 2012. View at Google Scholar
  15. M. Fekih, S. Fennira, L. Ghodhbane, and R. M. Zaouali, “Intracardiac thrombosis: on uncommon complication of Behcet's disease,” Tunisie Medicale, vol. 82, no. 8, pp. 785–790, 2004. View at Google Scholar · View at Scopus
  16. A. Kaya, C. Ertan, O. U. Gürkan et al., “Behçet's disease with right ventricle thrombus and bilateral pulmonary artery aneurysms: a case report,” Angiology, vol. 55, no. 5, pp. 573–575, 2004. View at Google Scholar
  17. K. Marc, G. Iraqui, A. Jniene, J. Benamor, and J. E. Bourkadi, “Intracardiac thrombus and pulmonary artery aneurysm in Behcet's disease,” Revue des Maladies Respiratoires, vol. 25, no. 1, pp. 69–72, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. J. K. Alkaabi and A. Pathare, “Pattern and outcome of vascular involvement of Omani patients with Behcet's disease,” Rheumatology International, vol. 31, no. 6, pp. 731–735, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. M. H. Houman, I. Ksontini, I. Ben Ghorbel et al., “Association of right heart thrombosis, endomyocardial fibrosis, and pulmonary artery aneurysm in Behçet's disease,” European Journal of Internal Medicine, vol. 13, no. 7, pp. 455–457, 2002. View at Publisher · View at Google Scholar · View at Scopus
  20. S. Hammami, S. Mahjoub, K. Ben-Hamda et al., “Intracardiac thrombus in Behçet’s disease: two case reports,” Thrombosis Journal, vol. 25, no. 3, pp. 1–9, 2005. View at Google Scholar
  21. D. Ernam, F. Atalay, A. Alp, and H. C. Hasanoǧlu, “A Behçet's disease patient with intracardiac thrombus, pulmonary artery aneurysms complicating recurrent pulmonary thromboembolism,” Tuberkuloz ve Toraks, vol. 54, no. 2, pp. 168–171, 2006. View at Google Scholar · View at Scopus
  22. L. A. Mendes, L. L. Macgraw, G. S. Aldea, and R. Davidoff, “Right ventricular thrombus: an unusual manifestation of Behçet’s disease,” Journal of the American Society of Echocardiography, vol. 7, no. 4, pp. 438–440, 1994. View at Google Scholar
  23. M. Piga, F. Puchades, I. Mayo, and D. D'Cruz, “Successful thrombolytic therapy for recurrent right ventricular thrombosis in Behçet's disease,” Clinical and Experimental Rheumatology, vol. 28, no. 4, supplement 60, pp. S76–S78, 2010. View at Google Scholar · View at Scopus
  24. N. Düzgün, C. Anıl, F. Özer, and T. Acican, “The disapperance of pulmonary artery aneurysms and intracardiac thrombus with immunosuppressive treatment in a patient with Behçet’s disease,” Clinical and Experimental Rheumatology, vol. 20, no. 4, supplement 26, pp. S56–S57, 2002. View at Google Scholar
  25. Y. Bayraktar, F. Balkancı, M. Bayraktar, and M. Calguneri, “Budd-Chiari syndrome: a common complication of Behçet's disease,” American Journal of Gastroenterology, vol. 92, no. 5, pp. 858–862, 1997. View at Google Scholar · View at Scopus
  26. F. E. El Louali, A. Tamdy, A. Soufiani et al., “Cardiac thrombosis as a manifestation of Behçet syndrome,” Texas Heart Institute Journal, vol. 37, no. 5, pp. 568–571, 2010. View at Google Scholar
  27. M. Yasuo, S. Nagano, Y. Yazaki et al., “Pulmonary embolism due to right ventricular thrombus in a case of Behçet’s disease,” Japanese Circulation Society, vol. 63, no. 11, pp. 909–911, 1999. View at Publisher · View at Google Scholar
  28. O. G. Göktekin, C. Korkmaz, B. Timualp et al., “Wide spread thrombosis associated with recurrent intracardiac thombus in a patient with Behçet’s disease,” The International Journal of Cardiovascular Imaging, vol. 18, no. 6, pp. 431–434, 2002. View at Google Scholar
  29. G. Hatemi, A. Silman, D. Bang et al., “EULAR recommendations for the management of Behçet disease,” Annals of the Rheumatic Diseases, vol. 67, no. 12, pp. 1656–1662, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. L. Caspary, “Vasculitides of large vessels,” Vasa, vol. 40, no. 2, pp. 89–98, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. K. T. Calamia, M. Schirmer, and M. Melikoğlu, “Major vessel involvement in Behçet’s disease,” Current Opinion in Rheumatology, vol. 17, no. 1, pp. 1–8, 2005. View at Google Scholar
  32. K. Özoran, N. Düzgün, A. Gürler, H. Tutkak, and G. Tokgöz, “Plasma von Willebrand factor, tissue plasminogen activator, plasminogen activator inhibitor, and antithrombin III levels in Behçet's disease,” Scand J Rheumatol, vol. 24, no. 6, pp. 376–382, 1995. View at Publisher · View at Google Scholar
  33. A. Gül, U. Özbek, C. Öztürk, M. Inanç, M. Koniçe, and T. Ozçelik, “Coagulation factor V gene mutation increases the risk of venous thrombosis in Behçet’s disease,” British Journal of Rheumatology, vol. 35, no. 11, pp. 1178–1180, 1996. View at Google Scholar
  34. P. B. Toydemir, A. H. Elhan, A. Tükün et al., “Effects of factor V gene G1691A, methylenetetrahydrofolate reductase gene C677T, and prothrombin gene G20210A mutations on deep venous thrombogenesis in Behcet's disease,” Journal of Rheumatology, vol. 27, no. 12, pp. 2849–2854, 2000. View at Google Scholar · View at Scopus
  35. M. la Regina, F. Orlandini, D. Prisco, and F. Dentali, “Homocysteine in vascular Behçet’s disease: a metaanalysis,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 30, no. 10, pp. 2067–2074, 2010. View at Publisher · View at Google Scholar
  36. J. Barkhausen, P. Hunold, H. Eggebrecht et al., “Detection and characterization of intracardiac thrombi on MR imaging,” American Journal of Roentgenology, vol. 179, no. 6, pp. 1539–1544, 2002. View at Google Scholar · View at Scopus
  37. D. Solmaz, I. Sari, E. Ozpelit, and E. Yilmaz, “Intracardiac thrombosis and superior vena cava syndrome in Behçet's disease,” Internal Medicine, vol. 50, no. 16, pp. 1787–1788, 2011. View at Publisher · View at Google Scholar · View at Scopus
  38. S. M. Dogan, A. Birdane, C. Korkmaz, N. Ata, and B. Timuralp, “Right ventricular thrombus with Behçet's syndrome successful treatment with warfarin and immunosuppressive agents,” Texas Heart Institute Journal, vol. 34, no. 3, pp. 360–362, 2007. View at Google Scholar · View at Scopus
  39. J. K. Ahn, Y. S. Lee, C. H. Jeon, E. M. Koh, and H. S. Cha, “Treatment of venous thrombosis associated with Behçet’s disease: immunosuppressive therapy alone versus immunosupressive thearpy plus anticoagulation,” Clinical Rheumatology, vol. 27, no. 2, pp. 201–205, 2008. View at Publisher · View at Google Scholar
  40. S. M. Samrah, S. S. Saadeh, and K. M. Alawneh, “Resolution of intracardiac and pulmonary thrombi without anticoagulation in a patient with Behçet's disease: a case report,” Clinical and Experimental Rheumatology. In press.
  41. A. Vivante, Y. Bujanover, J. Jacobson, S. Padeh, and Y. Berkun, “Intracardiac thrombus and pulmonary aneurysms in an adolescent with Behçet disease,” Rheumatology International, vol. 29, no. 5, pp. 575–577, 2009. View at Publisher · View at Google Scholar · View at Scopus
  42. Y. L. Zhu, Q. J. Wo, L. L. Guo et al., “The clinical characteristics and outcome of intracardiac thrombus and aortic valvular involvement in Behçet’s disease,” Clinical and Experimental Rheumatology, vol. 30, no. 3, supplement 72, pp. S40–S45, 2012. View at Google Scholar
  43. A. Moreno-Rodrigo, J. Muñoz-Sánchez, F. J. B. Bóveda-Romeo, and J. M. Santamaría-Jáuregui , “Intracardiac thrombosis associated with Behçet's disease,” Revista Española de Cardiología, vol. 63, no. 12, pp. 1513–1515, 2010. View at Google Scholar
  44. Y. Kaneko, K. Tanaka, A. Yoshizawa et al., “Successful treatment of recurrent intracardiac thrombus in Behçet's disease with immunosuppressive therapy,” Clinical and Experimental Rheumatology, vol. 23, no. 6, pp. 885–887, 2005. View at Google Scholar · View at Scopus
  45. I. Ben Ghorbel, Z. Ibn Elhadj, M. Khanfir et al., “Intracardiac thrombus in Behçet's disease. A report of three cases,” Journal des Maladies Vasculaires, vol. 29, no. 3, pp. 159–161, 2004. View at Google Scholar · View at Scopus
  46. K. Kırali, A. Civelek, B. Dağlar et al., “An uncommon complication of Behçet’s disease: ıntracardiac thrombosis needing surgical treatment,” The Journal of Thoracic and Cardiovascular Surgery, vol. 46, no. 2, pp. 102–105, 1998. View at Google Scholar
  47. L. M. Endo, S. M. Rowe, R. L. Romp, M. A. Buckmaster, and T. P. Atkinson, “Pulmonary aneurysms and intracardiac thrombi due to Behçet's disease in an African-American adolescent with oculocutaneous albinism,” Clinical Rheumatology, vol. 26, no. 9, pp. 1537–1539, 2007. View at Publisher · View at Google Scholar · View at Scopus