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Case Reports in Rheumatology
Volume 2014 (2014), Article ID 246852, 4 pages
http://dx.doi.org/10.1155/2014/246852
Case Report

Takayasu’s Arteritis and Crohn’s Disease in a Young Hispanic Female

1Immunology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, C42 E 10, Iowa City, IA 52241, USA
2Mercy Iowa City, 540 E Jefferson Street, Suite 205, Iowa City, IA 52245, USA
3Section of Rheumatology, Temple University Hospital, 3200 North Broad Street, Philadelphia, PA 19140, USA

Received 6 April 2014; Accepted 15 July 2014; Published 24 July 2014

Academic Editor: Helene Alexanderson

Copyright © 2014 Namrata Singh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Takayasu’s arteritis (TA) and Crohn’s disease (CD) are chronic inflammatory granulomatous disorders of undetermined etiology. TA is a large vessel vasculitis with a predilection for the aorta and its branches in young women of Asian descent; whereas CD has characteristic gastrointestinal manifestations more prevalent in young Caucasians. We describe a case of both diseases in a young Hispanic female, review the literature, and impart new insight on possible genetic linkage and the role of interleukin 12 B (IL-12B) as the common autoimmune mechanism and potential therapeutic target in this rare disease combination.