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Case Reports in Rheumatology
Volume 2014 (2014), Article ID 353782, 3 pages
Case Report

Relapsing Polychondritis in a Patient with Ankylosing Spondylitis Using Etanercept

1Division of Rheumatology, Department of Clinical Medicine, Federal University of Paraná, 80060-900 Curitiba, PR, Brazil
2Federal University of Paraná, 80060-900 Curitiba, PR, Brazil

Received 25 May 2014; Revised 19 August 2014; Accepted 19 August 2014; Published 9 September 2014

Academic Editor: Remzi Cevik

Copyright © 2014 Valderilio Feijó Azevedo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Relapsing polychondritis (RP) is an autoimmune disease characterized by recurrent episodes of inflammation and progressive destruction of cartilaginous tissues, especially of the ears, nose, joints, and tracheobronchial tree. Its etiology is not well understood, but some studies have linked its pathophysiology with autoimmune disease and autoantibody production. We described a case of a 46-year-old male patient with ankylosing spondylitis who developed RP after the use of etanercept. Few similar cases have been described in the literature. However, they show a possible association between the use of biological inhibitors of tumor necrosis factor (anti-TNFα), which potentially produces autoantibodies, and the development of RP. The treatment was based on data in the literature and included the cessation of biological therapy and the addition of corticosteroids with substantial improvement.