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Case Reports in Rheumatology
Volume 2014 (2014), Article ID 768321, 3 pages
Case Report

Kikuchi-Fujimoto Disease Associated with Symptomatic CD4 Lymphocytopenia

Department of Medicine, Interfaith Medical Center, 1545 Atlantic Avenue, Brooklyn, NY 11213, USA

Received 28 June 2014; Accepted 9 September 2014; Published 17 September 2014

Academic Editor: Tsai-Ching Hsu

Copyright © 2014 Meera Yogarajah and Bhradeev Sivasambu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Kikuchi-Fujimoto disease is a rare benign condition of necrotising histiocytic lymphadenitis with unknown aetiology. We describe here a 30-year-old African American female who presented with fever, generalized rash, cervical lymphadenopathy, and oral candidiasis and was found to have Kikuchi-Fujimoto disease on lymph node biopsy with low CD4 count. The initial presentation was concerning for acute retroviral infection. Her HIV serology and HIV RNA PCR were negative however she had low CD4 count with reversal of CD4/CD8 ratio. Although low CD4 count has been associated with autoimmune disease, it has not been described with Kikuchi-Fujimoto disease. We report the first case of Kikuchi-Fujimoto disease associated with symptomatic CD4 lymphocytopenia.