| | Constitutional | Malaise, myalgia, arthralgia, anorexia, weight loss, and pyrexia |
| | Mucocutaneous and orbital | Oral ulcers, oral granulomatous lesions, episcleritis, scleritis, conjunctivitis, keratitis, uveitis, retinal vasculitis, retinal artery or venous thrombosis, retinal exudates, retinal hemorrhages, blurred vision, blindness, proptosis, and orbital granulomatous masses |
| | Cutaneous | Infarcts leading to ulcers and gangrene; leukocytoclastic vasculitis that may be found on biopsy |
| | Ear and nose | Sensorineural and conductive hearing loss, persistent/recurrent nasal discharge +/− bloody, nasal ulceration, nose bridge collapse, nasal granulomatous lesions, and parasinus and sinus inflammation |
| | Upper airway | Subglottic or tracheal stenosis, stridor |
| | Lower airway | Cough, dyspnea, wheeze, hemoptysis, small airway obstruction, pulmonary infiltrates and hemorrhage leading to respiratory failure, and pleuritis |
| | Renal | Hematuria, proteinuria, cellular cast on urine cytology; renal impairment in the form of acute kidney injury, chronic kidney disease, or end stage renal disease; diffuse pauci-immune crescentic necrotizing glomerulonephritis on biopsy |
| | Cardiovascular | Occlusive vascular disease, pericarditis, pericardial effusions, cardiomyopathy, valvular heart disease, ischemic heart disease, and heart failure |
| | Gastrointestinal | Peritonitis, bowel ischemia secondary to mesenteric vasculitis |
| | Central and peripheral nervous systems | Headache, meningitis, seizures, cerebrovascular accidents, spinal cord lesions, cranial nerve palsies, sensory or motor peripheral neuropathy, mononeuritis multiplex, and cerebral mass lesion |
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