Case Report
Clinical and Diagnostic Considerations for Atypical, Adult Onset Presentation of Chronic Recurrent Multifocal Osteomyelitis (CRMO)
Table 1
Diagnostic criteria of NBO/CRMO.
| Major diagnostic criteria | Minor diagnostic criteria |
| 1. Radiologically proven osteolytic/sclerotic bone lesion | A. Normal blood count and good general state of health | 2. Multifocal bone lesions | B. CRP and ESR mildly to moderately elevated | 3. Palmoplantar pustulosis (PPP) or psoriasis | C. Observation time longer than 6 months | 4. Sterile bone biopsy with signs of inflammation and/or fibrosis, sclerosis | D. Hyperostosis | | E. Associated with other autoimmune diseases apart from PPP or psoriasis | | F. Grade I or II relatives with autoimmune or autoinflammatory disease or with NBO |
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Diagnostic criteria from Jansson et al. Diagnosis confirmed with 2 major criteria or 1 major and 3 minor criteria [ 14]. |