Acquired Factor VIII Deficiency Presenting as Gross Hematuria in a Hispanic, Pregnant Patient with Previously Undiagnosed Connective Tissue Disease

Table 1

Laboratory results.

Parameter	Patient	Reference range
PT	11.8 s	9.8–12.6 s
INR	1.05	0.87–1.15
PTT	92.1 s	24.3–36.7 s
Coagulation factor VIII activity	<1%	50–180%
Factor VIII inhibitor titer	74.9 BU	<0.6 BU
vWF Ag	190%	50–217%
vWF ristocetin cofactor	122%	42–200%
vWF Ag, multimeric	Normal
PTT-La screen	80 s	<40 s
Hexagonal phase confirm	Negative
DRVVT screen	22 s	<45 s
DNA ds Ab	0.9 IU/mL	<10 IU/mL
RNP 70	0.3 U/mL	<7.0 U/mL
Rheumatoid factor quantitative	44.6 IU/mL	<14.0 IU/mL
ANA	>32.0 ratio	>1.0 ratio
Cardiolipin Ab IgG	<14 GPL	< or = 14
Cardiolipin Ab IgM	<12 GPL	< or = 14
B2-glycoprotein IgM Ab	<9 GPL	< or = 20
B2-glycoprotein IgG Ab	<9 GPL	< or = 20
Anticentromere antibody	<0.4 U/mL	<7.0 U/mL
Jo 1 antibody	<0/3 U/mL	<7.0 U/mL
Scl 70 antibody	<0.6 U/mL	<7.0 U/mL
Smith antibody (Sm)	<0.8 U/mL	<7.0 U/mL
SS-A/Ro antibody	>240 U/mL	<7.0 U/mL
SS-B/La antibody	97 U/mL	<7.0 U/mL
U1RNP antibody	0.6 U/mL	<7.0 U/mL
Complement C3	174 mg/dL	87–200 mg/dL
Complement C4	20 mg/dL	19–52 mg/dL
Immunoglobulin A	242 mg/dL	66–443 mg/dL
Antistreptolysin O	<1 IU/mL	<250 IU/mL
ANCA	Negative
Urine culture	Negative
Random urine protein/creatinine ratio	858 mg/gm	161 mg/gm