Case Report

A Case of Effective Mepolizumab Induction Therapy for Severe Eosinophilic Granulomatosis with Polyangiitis Diagnosed by Eosinophilic Cholecystitis and Interstitial Nephritis

Table 1

Results of the complete blood count, biochemistry, and urinalysis at admission.

Hematology
 White blood cells14300/μL
 Eosinophils8000/μL
 Red blood cells432 × 104/μL
 Hemoglobin14.1 g/dL
 Platelet29.0 × 104/μL
Biochemistry
 Total protein7.7 g/dL
 Albumin2.9 g/dL
 AST50 IU/L
 ALT94 IU/L
 LDH310 IU/L
 Total bilirubin0.5 mg/dL
 Creatinine0.96 mg/dL
 Blood urea nitrogen11 mg/dL
 Sodium136 mmol/L
 Potassium3.8 mmol/L
 Chloride100 mmol/L
 C-reactive protein7.4 mg/dL
 sIL-2R3077 IU/mL
Infection
 Interferon-γ release assayNegative
 HIV AbNegative
Immunology
 Immunoglobulin G2209 mg/dL
 Immunoglobulin G41220 mg/dL
 Immunoglobulin A97 mg/dL
 Immunoglobulin M87 mg/dL
 Immunoglobulin E2482 IU/mL
 Rheumatoid factor123 IU/mL
 Antinuclear Ab<40×
 Anticardiolipin Ab<8 IU/mL
 MPO-ANCA<1.0 IU/mL
 PR3-ANCA<1.0 IU/mL
 Anti-GBM Ab<2.0 IU/mL
 C3103 mg/dL
 C424 mg/dL
Urinary
 pH7.5
 Specific gravity1.020
 Urine protein1.37 g/gCre
 Red blood cells1/HPF
 White blood cells1–4/HPF
β2-microglobulin7137 μg/L
 NAG43 IU/L

Ab, antibody; ALT, alanine aminotransferase; AST, aspartate aminotransferase; GBM, glomerular basement membrane; HIV, human immunodeficiency virus; HPF, high power field; IU, international unit; LDH, lactate dehydrogenase; MPO-ANCA, myeloperoxidase-antineutrophil cytoplasmic antibody; NAG, N-acetyl-β-D-glucosaminidase; PR3-ANCA, proteinase-3-antineutrophil cytoplasmic antibody; sIL-2R, soluble interleukin-2 receptor antibody.