Nephrotic Syndrome as an Extramuscular Manifestation of Anti-EJ Antibody-Positive Dermatomyositis: A Case Report and Review of the Literature

Figure 3

Renal biopsy showing deposition of immunoglobulin G (IgG) and complement 3 (C3) in a woman who developed recurrent anti-glycyl tRNA synthetase (EJ) antibody-positive dermatomyositis concurrently with newly developed nephrotic syndrome. (a) Hematoxylin and eosin (HE) stain; (b) periodic acid methenamine silver (PAM) stain; immunofluorescence examination: (c) total IgG; (d) IgG1; (e) IgG2; (f) IgG3; (g) IgG4; (h) C3. Light microscopic examinations using HE and PAM stains show neither thickening nor spike formation of basement membranes. Deposition of IgG, IgG1, IgG2, IgG4, and C3 is noted. Immunoglobulin A (IgA) and immunoglobulin M (IgM) are absent (data not shown).

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