Case Reports in Rheumatology

Case Series

Concurrence of Rheumatoid Arthritis and Ankylosing Spondylitis: Analysis of Seven Cases and Literature Review

Table 1

Literature review on coexistence of rheumatoid arthritis and ankylosing spondylitis.
AuthorNo.SexAge (years)1st symptomOnset (years)1st diseaseDuration (years)NodulesRFAc. CCPHLA B-27Lumbar painSISindErosUveitisExtra-art involv
Wilkinson and Bywaters1M55Arthritis22RA33++NANA++NS++0
Martel and Duff2M47Arthritis18RA290+NANA++0+00
 3F32Arthritis30RA2++NANA++++00
 4F27Arthritis15RA12++NANA0+++00
 5F42Arthritis24RA18++NANA0+NS+0+
 6M52Arthritis21RA31++NANA0+++0+
 7M37Arthritis29RA800NANA++NS+++
 8M54Arthritis43RA9++NANA+0NS+00
London and Bland9M26Arthritis14RA12+NSNANA++NSNS00
Rosenthal et al. [8]10M73Uveitis22AE51++NANA+++NS++
Husskisson et al. [37]11M80L. pain25AE55++NANA+++++0
Valkenburgh et al. [9]12F45Arthritis36RA9++NANA++NS+++
Luthrah et al. [10]13M59L. pain34AE25++NA+++++00
 14M65L. pain48AE17++NA+++++00
Querol et al. [11]15M40L. pain18AE2200NA+++0000
 16F46L. pain27AE190+NA+++0+00
 17M51L. pain25AE26+0NA++++000
 18M50L. pain42AE800NA++++000
 19M53L. pain41AE12++NA+++++00
 20M17L. pain15AE20+NA+0+0+00
 21M28L. pain15AE1300NA+++0000
Fallet et al. [35]22M64L. pain30AE34++NA+++++00
 23M68Arthritis29RA390+NA+NS+NS++0
 24F68Arthritis65RA3++NA+0+NS000
 25M54Arthritis40RA14++NA+++NS+00
 26M67Arthritis57RA100+NA0++++00
 27F75Arthritis63RA120+NA+++++00
 28F58Uveitis42RA160+NA+0+NS++0
 29M68L. pain29AE390+NA+++NS+00
 30M44Myalgias36AE8++NA+++NS+00
Good et al. [12]31MNSL. pain29AENS0+NA+++++00
 32MNSL. pain20AENS0+NA+++++00
 33MNSL. pain34AENS0+NA+++0+00
Clayman and Reinertsen34M48L. pain21AE27++NA++++000
Espinoza et al. [14]35M53L. pain47AE6++NA+++NS+00
Major et al. [15]36M64L. pain28AE36++NA+++++00
 37M61L. painNSAENS0+NA+++++00
Lemmer and Irby38M51L. pain26AE25++NA+++++0+
Alexander et al. [17]39M55Arthritis32RA23++NA+++NS+0+
 40M61Arthritis54RA7++NA+0+++0+
 41MNSNSNSNSNS++NA0NS+NS000
 42MNSNSNSNSNS++NA0NS+NS+00
 43MNSNSNSNSNS++NA+NS+NS+00
Lavery et al. [18]44M60L. pain18AE42++NA+++NS+++
Alarcón Segovia and Martínez-Cordero45M70L. painNSNSNS++NA+++++00
Serrano et al. [20]46M35NS22RA13NS+NA+++NSNS0+
Fallet et al. [21]47M52Arthritis25RA270+NA+++++++
 48M60L. pain48AE12++NA+++++00
 49M61Arthritis40NS110+NA+0+0+00
 50M56L. pain22AE340+NA+++++++
 51M66Arthritis61RA5++NA+++0+00
 52M71L. pain21AE50++NA+++++00
 53M49Arthritis35RA140+NA+++0+00
 54F83Arthritis69RA140+NA+++++00
Helfgott et al. [22]55M77L. pain39AE38++NA+++++00
Sattar et al. [23]56M35L. pain25AE100+NA0++++++
Martínez-Cordero et al. [24]57M38Arthritis28RA10NS+NA+++++00
Ferreiro Seoane et al. [25]58M44L. pain31AE13++NA+++NS+0+
Toussirot and Acquaviva59M48Arthritis22RA26++NA00+0+00
 60M77Arthritis35RA420+NA0++++00
 61F27Arthritis19RA80+NA+++0+00
Genc et al. [27]62F62Arthritis52RA10NS0NA+++++0+
Guo et al. [28]63F30L. pain23AE70+++++NS+00
Baksay et al. [29]64F57L. pain25AE32NS+++++++00
Feijo et al. (2011)65F65L. pain64AE10+++++++00
Aghdashi et al. [31]66F70Arthritis58RA12NS+++0+++00
Dundar et al. [32]67M63L. pain51RA12NS++NS++NS+00
Koca et al. [38]68F38L. pain38RA10++0++0000
Barczynska et al. [33]69F55Arthritis35RA20++++++++00
 70M56L. pain34AE22NS+0+++++00
 71M65NSNSNSNSNS+0+++++00
Baccouche et al. [34]72F21L. pain20AE10+++++++00
Sargin and Gurer73F47L. pain45RA20NSNSNS++NSNS00
Haridas and Kiran74F32Arthritis32AR10+++++NSNS00
Flores-Robles et al. (2020)75M55L. pain41AE140++++++000
 76F43Arthritis35RA80+++++0+00
 77F64Arthritis51RA130+++0+0000
 78M57Arthritis28RA29++++0+0+00
 79M64L. pain49AE150++++++000
 80M63Arthritis47RA160+++++++00
 81F75Arthritis70RA50+++++++00
Ac. CCP: citrullinated peptide antibodies; AE: ankylosing spondylitis; Eros: radiographic erosions on hands and/or feet; extra-art involv: extra-articular involvement; F: female; L. pain: lumbar pain; M: male; NA: not applicable; NS: not specified by the author; RA: rheumatoid arthritis; RF: rheumatoid factor; SI: radiological sacroiliitis; Sind: spine syndesmophytes; sign +: existence/positive; sign 0: absence/negative.