Risk Factors, Prognosis, Influence on the Offspring, and Genetic Architecture of Perinatal Depression Classified Based on the Depressive Symptom Trajectory

Table 3

Significant or top-hit variants in any PD or PD subtypes.

Chr

RSID

Position

Ref

Alt

EA

Function

Gene

JPA v2

JPA NEO

Meta-analysis

EA freq.

Beta

SE

value

EA freq.

Beta

SE

value

value

Direction

Any PD

21

rs138801403

37521946

G

A

A

ncRNA_intronic

CBR3–AS1

0.012

0.84

0.19

0.013

0.64

0.20

++

Pregnancy PD

9

rs1853229

10503904

C

T

T

Intronic

PTPRD

0.021

0.90

0.22

0.021

0.98

0.26

++

Early postpartum PD

15

rs117741236

43555394

A

G

G

Intronic

TGM5

0.023

1.01

0.24

0.027

0.90

0.26

++

Late postpartum PD

5

rs1075046

22852984

C

G

G

Intronic

CDH12

0.546

–0.31

0.10

0.549

–0.63

0.12

—

Late postpartum PD

16

rs4786119

6803436

T

C

C

Intronic

RBFOX1

0.615

–0.38

0.11

0.609

–0.57

0.12

—

Chronic PD

1

rs56289435

99692247

CACACAA

C

C

Intergenic

LOC100129620/PLPPR4

0.498

–0.20

0.07

0.500

–0.37

0.07

—

PD: perinatal depression; JPA v2: Japonica Array v2; JPA NEO: Japonica Array NEO; Ref: reference allele; Alt: alternative allele; EA: effect allele; EA freq: EA frequency; SE: standard error; ncRNA: noncoding RNA. The direction column indicates whether variants were positively or negatively associated with outcomes in each of the two cohorts.