Targeted Disruption of Calcium/NFAT Signaling Reveals a Left-Right Determination Disorder in the Pharyngeal Arch Artery

Table 1

Appearance of right aortic arch after injection to mother mouse.

Drugs	𝑁 of fetuses	% of right aortic arch + right ductus arteriosus	% of other abnormalities
FK506
6.0 mg/kg	3	0	33
3.0 mg/kg	31	32	0
0.8 mg/kg	30	23	3
0.05 mg/kg	13	0	0
Saline	34	0	0
FTY720
6.0 mg/kg	8	0	0
3.0 mg/kg	26	0	0
Saline	32	0	0
Rapamycin
1.0 mg/kg	8	0	0
0.1 mg/kg	16	0	0
0.01 mg/kg	14	0	0
Saline	24	0	0

Injection was performed during 6.5, 7.5, and 8.5 days after pregnancy.