Table of Contents
Dataset Papers in Science
Volume 2013 (2013), Article ID 520285, 5 pages
http://dx.doi.org/10.1155/2013/520285
Dataset Paper

DNA Microarray Assay Helps to Identify Functional Genes Specific for Leukemia Stem Cells

1Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA
2Division of Hematology/Oncology, Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA

Received 20 May 2013; Accepted 7 July 2013

Academic Editors: M. Jernas, N. Li, and K. Valerie

Copyright © 2013 Haojian Zhang and Shaoguang Li. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Wong and O. N. Witte, “The BCR-ABL story: bench to bedside and back,” Annual Review of Immunology, vol. 22, pp. 247–306, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. J. V. Melo and D. J. Barnes, “Chronic myeloid leukaemia as a model of disease evolution in human cancer,” Nature Reviews Cancer, vol. 7, no. 6, pp. 441–453, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Savona and M. Talpaz, “Getting to the stem of chronic myeloid leukaemia,” Nature Reviews Cancer, vol. 8, no. 5, pp. 341–350, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. R. Ren, “Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia,” Nature Reviews Cancer, vol. 5, no. 3, pp. 172–183, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. B. J. Druker, C. L. Sawyers, H. Kantarjian et al., “Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome,” New England Journal of Medicine, vol. 344, pp. 1038–1042, 2001. View at Publisher · View at Google Scholar
  6. B. J. Druker, M. Talpaz, D. J. Resta et al., “Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia,” New England Journal of Medicine, vol. 344, no. 14, pp. 1031–1037, 2001. View at Publisher · View at Google Scholar · View at Scopus
  7. B. J. Druker, S. Tamura, E. Buchdunger et al., “Effects of a selective inhibitor of the Ab1 tyrosine kinase on the growth of Bcr-Ab1 positive cells,” Nature Medicine, vol. 2, no. 5, pp. 561–566, 1996. View at Google Scholar · View at Scopus
  8. B. J. Druker, F. Guilhot, S. G. O'Brien et al., “Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia,” New England Journal of Medicine, vol. 355, no. 23, pp. 2408–2417, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. S. M. Graham, H. G. Jørgensen, E. Allan et al., “Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro,” Blood, vol. 99, no. 1, pp. 319–325, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. Y. Hu, S. Swerdlow, T. M. Duffy, R. Weinmann, F. Y. Lee, and S. Li, “Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 45, pp. 16870–16875, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. A. S. Corbin, A. Agarwal, M. Loriaux, J. Cortes, M. W. Deininger, and B. J. Druker, “Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity,” Journal of Clinical Investigation, vol. 121, no. 1, pp. 396–409, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. H. Zhang, C. Peng, Y. Hu et al., “The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells,” Nature Genetics, vol. 44, pp. 861–871, 2012. View at Publisher · View at Google Scholar
  13. Y. Hu, Y. Liu, S. Pelletier et al., “Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia,” Nature Genetics, vol. 36, no. 5, pp. 453–461, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. C. Peng, J. Brain, Y. Hu et al., “Inhibition of heat shock protein 90 prolongs survival of mice with BCR-ABL-T315I-induced leukemia and suppresses leukemic stem cells,” Blood, vol. 110, no. 2, pp. 678–685, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. S. Li, R. L. Ilaria Jr., R. P. Million, G. Q. Daley, and R. A. Van Etten, “The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity,” Journal of Experimental Medicine, vol. 189, no. 9, pp. 1399–1412, 1999. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Li and D. Li, DNA Microarray Technology and Data Analysis in Cancer Research, World Scientific, 2009.
  17. Y. Chen, Y. Hu, H. Zhang, C. Peng, and S. Li, “Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia,” Nature Genetics, vol. 41, no. 7, pp. 783–792, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. H. Zhang, H. Li, N. Ho, D. Li, and S. Li, “Scd1 plays a tumor-suppressive role in survival of leukemia stem cells and the development of chronic myeloid leukemia,” Molecular and Cellular Biology, vol. 32, pp. 1776–1787, 2012. View at Publisher · View at Google Scholar