The In Vitro Susceptibility of Biofilm Forming Medical Device Related Pathogens to Conventional Antibiotics

Figure 5

Log₁₀ graph showing kill kinetics and Log₁₀ planktonic viable counts (Log₁₀ CFU mL⁻¹) of MRSA (ATCC 43300) (positive control: filled circles, full line) over a period of 24 hours of exposure to four times MIC value (mg L⁻¹) of active standard antimicrobials (vancomycin 10 mg L⁻¹: filled square, dotted line; rifampicin 10 mg L⁻¹: filled triangle, full line; gentamicin 2 mg L⁻¹: open square, dotted line; trimethoprim 250 mg L⁻¹: open triangle, dotted line; ciprofloxacin 31.25 mg L⁻¹: full circle, full line) based on five replicates. No standard antimicrobial was active against the biofilm form of MRSA (ATCC 43300) at concentrations (≤1000 mg L⁻¹) tested and thus kinetic analysis was not performed.