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Diagnostic and Therapeutic Endoscopy
Volume 4, Issue 4, Pages 173-176
http://dx.doi.org/10.1155/DTE.4.173

A Clinical Study of Photodynamic Therapy for Superficial Esophageal Carcinoma by YAG-OPO Laser

1Department of Gastrointestinal Endoscopy, Tokyo Women's Medical College, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162, Japan
2Department of Gastroenterology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan
3Second Department of Surgery, Wakayama Medical College, Japan
4Second Department of Surgery, Japan
5Department of Endoscopic Diagnostics and Therapeutics, Chiba University, Japan
6Department of Internal Medicine, University of Tsukuba, Japan
7Department of Gastroenterology, Chiba Nishi General Hospital, Japan
8Department of Gastroenterological Surgery, Tokyo Women's Medical College, Japan
9First Department of Surgery, Tokyo Medical College, Japan

Received 16 May 1997; Accepted 15 October 1997

Copyright © 1998 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A cooperative clinical study of photodynamic therapy (PDT) for superficial esophageal carcinoma was conducted at 6 medical institution. PHE (2mg/kg) with high tumor affinity was used as the oncotropic compound. The light source was a pulse wave YAG-OPO laser with high penetration into the tissue. Irradiation was performed at an energy density of 60–180 J/cm2 48–72 h after PHE administration. Eight lesions in 6 patients were treated. All were type 0-II superficial carcinomas. The depth of invasion was EP–MM for 6 lesions and SM for 2 lesions. A complete response (CR) was achieved in all patients after one session of PDT. Five adverse events, including anemia and fever, were reported by 4 patients, but all were WHO grade 2 or lower and transient. PDT using PHE and YAG-OPO laser was therefore considered effective as a curative therapy for superficial esophageal carcinoma.