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Diagnostic and Therapeutic Endoscopy
Volume 5 (1999), Issue 2, Pages 91-98

Detection of Bronchial Neoplasia in Uranium Miners by Autofluorescence Endoscopy (SAFE-1000)

1Masaryk Memorial Cancer Institute, Zluty kopec 7, Brno CZ-65653, Czech Republic
2Clinic of Respiratory Medicine, Masaryk University Hospital, Bohunice, Brno, Czech Republic
3Department of Pathology, Medical College Hospital of Johann Gregor Mendel, Brno, Czech Republic
4Department of Pneurnology, Uranium Mines Hospital, Pribram, Czech Republic
5Third Clinic of surgery, Charles University Hospital Motol, Prague, Czech Republic
6Department of Respiratory Medicine, Hospital Decin, Czech Republic

Copyright © 1999 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The increase in the detection rate for premalignant changes of bronchial epithelium was studied in 56 symptom-free volunteers from the risk group of Czech uranium miners (mean age 50.69 years, mean WLM 21.06 (1 Working Level Month is equal to the absorption of latent energy of 2.08 × 10–5 J/m3 in one month, i.e. 170 working hours)) by the additional employment of the System of Autofluorescence Endoscopy (SAFE-1000 Pentax) to conventional white-light bronchoscopy, comparing results with those of bronchial biopsy histopathology examination. Histopathology using hematoxylin and eosin staining confirmed intraepithelial neoplasias in 15 areas in 10 persons. White-light bronchoscopy sensitivity was 21.05%, and specificity 93.7% which an autofluorescence bronchoscopy sensitivity was 78.95% and specificity 81.89%.