Figure 1: Expression of COX-2 in murine models of colitis, sporadic, and colitis-associated colorectal cancer. (a) Quantitative real-time PCR of COX-2 mRNA levels in control and inflamed colon tissue, small and large AOM + DSS induced tumors, and tumors of APCmin mice. Data are mean SEM. per group. (b) Multispectral in vivo fluorescence imaging following the injection of a COX-2-specific fluorescence probe. One representative image of an APCmin mouse in comparison to a control animal is shown.