Figure 1: We defined lesions which satisfied both following conditions by NBI with magnification as “NBI-positive”; (1) well-demarcated brownish area, and (2) abnormal changes of intraepithelial papillary capillary loop (IPCL) pattern, that were dilatation, tortuosity, and caliber change in a single IPCL, and variation in the shape of multiple IPCL. We defined lesions which satisfied either or neither of them as “NBI negative.” The abnormal blood vessels observed in Case 2 seemed to reflect neovascularization after chemoradiotherapy, so the lesion was judged to be negative for IPCL abnormality.