Research Article

Capsule Endoscopy for Obscure Gastrointestinal Bleeding in Patients with Comorbid Rheumatic Diseases

Table 1

Demographic and clinical characteristics of included cases.

Characteristics Negative CE ( ) Positive CE ( ) value RHEUM CE ( ) Non-RHEUM CE ( ) value
(%)SD (%)SD (%)SD (%)SD

Mean age (years)64.5017.0567.689.590.44966.4412.9163.1915.260.183
Gender (male)3 (18.8)8 (32.0)0.47811 (26.8)321 (51.2)0.003
Status (inpatient)2 (12.5)6 (24.0)0.4488 (19.5)42 (6.7)0.008
Indication for CE0.1210.483
 Occult5 (31.3)14 (56.0)19 (46.3)326 (52.0)
 Overt11 (68.8)11 (44.0)22 (53.7)301 (48.0)
Occult breakdown
 Anemia1 (20.0)0 (0)1 (5.3)18 (2.9)
 IDA3 (60.0)4 (28.6)7 (36.8)130 (20.7)
 FOBT+1 (20.0)10 (71.4)11 (57.9)178 (28.4)
Overt breakdown
 Hematemesis1 (6.3)0 (0)1 (2.4)9 (1.4)
 Hematochezia4 (25.0)4 (16.0)8 (19.5)124 (19.8)
 Melena6 (37.5)8 (32.0)14 (34.2)193 (30.8)
Duration of problem0.8650.309
 0–8 weeks 2 (12.5)3 (12.0)5 (12.2)44 (7.0)
 9–24 weeks2 (12.5)2 (8.0)4 (9.8)51 (8.1)
 >24 weeks12 (75.0)20 (80.0)32 (78.1)532 (84.9)
Mean EGDs1.630.961.961.810.5071.831.531.841.090.956
Mean enteroscopies0.380.500.520.510.3930.460.500.561.070.553
Mean colonoscopies1.560.811.560.711.0001.560.741.901.170.067
Excessive alcohol 0 (0)1 (4.0)1.0001 (2.4)43 (6.9)0.510
Smoking0 (0)1 (4.0)1.0001 (2.4)65 (10.4)0.169
NSAIDs2 (12.5)7 (28.0)0.4419 (22.0)23 (3.7)<0.001
Antiplatelet/coagulation 4 (25.0)5 (20.0)0.7179 (22.0)97 (15.5)0.271
Oral steroids4 (25.0)8 (32.0)0.73412 (29.3)16 (2.6)<0.001
Proton pump inhibitors12 (75.0)15 (60.0)0.32327 (65.9)252 (40.2)0.001
Number of transfusions0.6230.842
 0 units6 (37.5)5 (20.0)11 (26.8)177 (28.2)
 1-2 units1 (6.3)3 (12.0)4 (9.8)68 (10.9)
 3–9 units4 (25.0)6 (24.0)10 (24.4)181 (28.9)
 ≥10 units5 (31.3)11 (44.0)16 (39.0)201 (32.0)

CE: capsule endoscopy; EGDs: esophagogastroduodenoscopies; FOBT+: fecal occult blood test positive; IDA: iron deficiency anemia; NSAIDs: nonsteroidal anti-inflammatory drugs; SD: standard deviation.