High Definition Colonoscopy Combined with i-SCAN Imaging Technology Is Superior in the Detection of Adenomas and Advanced Lesions Compared to High Definition Colonoscopy Alone

Table 4

In vivo studies of i-SCAN in real-time evaluation of colonic pathology.

Author/year/reference		Major findings/conclusions
Hoffman et al., 2010 [16]	69	i-SCAN can detect and identify small adenomatous polyps as well as standard chromoendoscopy in the distal 30 cm of the colon
Hoffman et al., 2010 [17]	220	i-SCAN detects more colorectal neoplasia compared to standard video endoscopy; i-SCAN can accurately predict polyp histology
Lee et al., 2011 [22]	142	i-SCAN and narrow band imaging (NBI) have similar efficacy in predicting histology of diminutive polyps compared to high definition white light colonoscopy (both superior to HDWLE)
Testoni et al., 2012 [21]	1101	Compared to standard white light colonoscopy, i-SCAN detects more polyps, specifically flat and small polyps (<10 mm)
Chan et al., 2012 [18]	75	i-SCAN and HDWLE have similar efficacy in predicting small polyp (<10 mm) histology during colonoscopy
Hong et al., 2012 [20]	389	i-SCAN did not detect more polyps or adenomas compared to HDWLE; i-SCAN in mode 2 better predicted polyp histology than HDWLE
Testoni et al., 2013 [23]	542	Nonexpert endoscopists had a similar detection rate of mucosal lesions compared to expert endoscopists when using i-SCAN; when using standard WLE experts detected more lesions than nonexperts
Basford et al., 2014 [19]	84	A single endoscopist was able to predict histology of small polyps (<10 mm) with high accuracy using both HDWLE and i-SCAN; there was no difference in prediction between i-SCAN and HDWLE (both met ASGE performance thresholds)
Bowman, present	1936	i-SCAN detects more adenomas and advanced polyps compared to high definition white light endoscopy