Clinical Characteristics, Treatment, and Prognosis of Amoxicillin-Induced AGEP/ALEP

Table 1

Basic characteristics of the 46 patients included.

Parameters	Results
Sex (45)^a
M	23 (50.0%)
F	22 (47.8%)
Age
Years	40 (1.4, 87)^b
Country
China	11 (23.9%)
Germany	5 (10.9%)
Italy	3 (6.5%)
America	3 (6.5%)
Portugal	3 (6.5%)
UK	3 (6.5%)
Japan	3 (6.5%)
Australia	2 (4.3%)
Belgium	2 (4.3%)
Spain	2 (4.3%)
Netherlands	2 (4.3%)
Canada	1 (2.2%)
Denmark	1 (2.2%)
Greece	1 (2.2%)
Iran	1 (2.2%)
Poland	1 (2.2%)
Switzerland	1 (2.2%)
Turkey	1 (2.2%)
Types of drugs
Amoxicillin	23 (50.0%)
Amoxicillin/clavulanate	23 (50.0%)
Route of administration (21)^a
Po	20 (43.5%)
Intravenous	1 (2.2%)
Onset time (43)^a
Days	2.5 (0.25, 28)^b
Within 12 h	5 (10.9%)
1–3	25 (54.3%)
4–7	8 (17.4%)
8–28	5 (10.9%)
Medical history
AF, CHD, COPD, CVA, DU, CHD, T2DM, kidney disease, hypertension, congenital cardiac valve defect, migraine with aura, and hypercholesterolemia	6 (13.0%)
Concurrent medications	12 (26.1%)
Medical histories of dermatologic
Atopic dermatitis, acne, drug rash, pustular lesions, and psoriasis vulgaris	6 (13.0%)
Allergy history
Amoxicillin and penicillin	6 (13.0%)
Indication (42)^a
Respiratory tract infection	17 (37.0%)
Surgical prophylaxis	5 (10.9%)
Dental prophylaxis	5 (10.9%)
Dental infection	5 (10.9%)
Urinary tract infection	2 (4.3%)
Skin soft tissue infection	2 (4.3%)
Arthritis	2 (4.3%)
Bartholin’s cyst	1 (2.2%)
Otitis media	1 (2.2%)
Sinusitis	1 (2.2%)
Fever of unknown origin	1 (2.2%)

AF: atrial fibrillation; CHD: congestive heart failure; COPD: chronic obstructive pulmonary disease; CVA: cough variant asthma; CHD: coronary heart disease; DU: duodenal ulcers; T2DM: type 2 diabetes mellitus. ^aThe number of patients out of 46 about whom information regarding this particular parameter was provided. ^bMedian (minimum-maximum).